Therapeutic phenethylamine compositions and methods of use
AssigneeCybin IRL Limited
InventorsAlex Belser, Clinton E. Canal, Brett J. Greene, Joshua A. Hartsel, Alex Nivorozhkin, Michael Palfreyman
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Abstract
There are disclosed deuterated 2C—X phenethylamine compounds, the use of such compounds in the treatment of diseases associated with a serotonin 5-HT2 receptor, pharmaceutical compositions such as tablet compositions and kits containing the compounds, methods of delivering the compounds in a mist via inhalation, and methods of treating diseases or disorders associated with a serotonin 5-HT2 receptor, such as central nervous system (CNS) disorders or psychological disorders with the compounds of the invention.
Claims13
A compound having a structure of formula (I):
- or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof,
- wherein:
- X1 and X2 are independently hydrogen or deuterium;
- Y1 and Y2 are independently hydrogen or deuterium;
- R3 is hydrogen or deuterium,
- R4 is —SCF3;
- and
- each Ra is independently a substituted or unsubstituted C1-C6 alkyl,
- wherein any position in the compound indicated as having deuterium has a minimum deuterium incorporation of at least 10 atom % at the site of deuteration.
Dependencies are inferred from the claim text.