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US 12,121,630 B2Granted
Light activated adhesive scaffold
AssigneeMassachusetts Eye and Ear Infirmary
InventorsRoholah Sharifi, Miguel Gonzalez Andrades, James Chodosh
Life of this patent
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Abstract
The present invention discloses compositions and methods for repair and reconstruction of defects and injuries to soft tissues. Some aspects of the disclosure provide methods for corneal reconstruction by applying an engineered bioadhesive, glycidyl methacrylate-substituted gelatin and a visible light activated photoinitiator in presence of visible light to the corneal defect.
Claims18
A method for treating a corneal injury or a corneal defect, comprising:
- a) applying a glycidyl methacrylate-substituted gelatin and a visible light-activated photoinitiator to the corneal injury or the corneal defect;
- and
- b) applying visible light to activate the visible light-activated photoinitiator and cross-linking the glycidyl methacrylate-substituted gelatin to form a cross-linked glycidyl methacrylate-substituted gelatin,
- wherein the glycidyl methacrylate-substituted gelatin has a degree of functionalization of gelatin with glycidyl methacrylate between 50% and 180% with respect to the amine groups of gelatin.
1 more element
A method for treating a soft tissue injury or wound, comprising:
- applying a cross-linked glycidyl methacrylate-substituted gelatin to a corneal injury or a corneal defect.
Dependencies are inferred from the claim text.