High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers
AssigneeThe Board of Trustees of the University of Illinois
InventorsKing C Li, Jeffrey S Moore
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Abstract
Provided herein are compositions and methods for remotely and non-invasively subjecting targeted biological structures with light emissions or chromogenic changes.
Claims17
A composition comprising a chromogenic or luminescent mechanophore covalently linked to a gel matrix, wherein the chromogenic or luminescent mechanophore is present in the gel matrix at about 1.0 wt % to about 5 wt %, wherein the chromogenic or luminescent mechanophore is naphthopyran, dioxetane, spiropyran, maleimide, or tetraarylsuccinonitrile tetraol, and wherein one or more types of genetically modified cells that express one or more recombinant light sensitive proteins are present within the gel matrix.
A composition comprising a chromogenic or luminescent mechanophore covalently linked to a gel matrix, wherein the chromogenic or luminescent mechanophore is present in the gel matrix at about 1.0 wt % to about 5 wt %, wherein the chromogenic or luminescent mechanophore is naphthopyran, dioxetane, spiropyran, maleimide, or tetraarylsuccinonitrile tetraol, and wherein one or more types of genetically modified cells are present within the gel matrix, wherein the composition further comprises an energy acceptor.
A composition comprising anthracene covalently linked to a gel or elastomer matrix, wherein the anthracene is present in the gel or elastomer matrix at about 1.0 wt % to about 5 wt %, wherein one or more types of genetically modified cells that express one or more recombinant light sensitive proteins are present within the gel or elastomer matrix.
A composition comprising a chromogenic or luminescent mechanophore covalently linked to a gel or elastomer matrix, wherein the chromogenic or luminescent mechanophore is present in the gel or elastomer matrix at about 1.0 wt % to about 5 wt %, wherein one or more types of genetically modified cells are present within the gel or elastomer matrix, and wherein the composition further comprises an energy acceptor that is different from the chromogenic or luminescent mechanophore.
Dependencies are inferred from the claim text.