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US 12,121,580 B2Granted
Antibacterial photodynamic therapy using copper-cysteamine nanoparticles
AssigneeBoard of Regents, The University of Texas System
InventorWei Chen
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Abstract
The uses of the disclosed copper-cysteamine (Cu-Cy) complex for methods for treating Gram-positive and Gram-negative infections in subjects and for disinfecting a surface are disclosed. In addition, the disclosed Cy-Cy nanoparticles provide Fenton-like reactions in vivo, in vitro and ex vivo.
Claims6
A method for treating a bacterial infection in a subject, comprising:
- a) administering to a subject having a bacterial infection an effective amount of nanoparticles containing a compound having the formula:
- Cu3Cl(SR)2
- wherein R is —CH2CH2NH2 such that the bacteria are in contact with the compound;
- and
- b) exposing the compound to a photo-activating amount of electromagnetic radiation at a wavelength that activates the compound.
2 more elements
Dependencies are inferred from the claim text.