Materials and methods for treatment with oncolytic viruses and modified CAR T cells
AssigneesMayo Foundation for Medical Education and Research, Duke University
InventorsLaura Evgin, Richard G. Vile, Luis Sanchez-Perez
Life of this patent
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Abstract
This document relates to methods and materials involved in treating cancer. For example, methods and materials for using one or more oncolytic viruses (OVs) in combination with an adoptive cell therapy (e.g., a chimeric antigen receptor T cell therapy) to alter one or more functions of a T cell and/or to enhance T cell expansion to treat cancer in a mammal (e.g., a human) are provided.
Claims20
A method for treating a mammal having cancer, the method comprising administering to the mammal:
- (a) an oncolytic virus (OV), wherein the virus induces expression of type I interferon (IFN), and
- (b) genetically modified T cells with reduced expression of interferon-α/β receptors (IFNARs).
A method for treating a mammal having cancer, wherein said method comprises administering, to said mammal, (a) a viral vector, wherein said viral vector induces expression of type I interferon (IFN) within said mammal, and (b) genetically modified T cells with reduced expression of interferon-α/β receptors (IFNARs).
Dependencies are inferred from the claim text.