Localized cooling to induce browning of adipose tissue
AssigneeThe General Hospital Corporation
InventorsDieter Manstein, Michael Evers, Nunciada Salma
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Abstract
Described are methods for inducing browning of adipose tissue. More specifically, the present disclosure relates generally to methods for inducing browning of adipose tissue remote to the treatment location. The methods can include at least a first treatment and a second treatment, wherein the treatments comprise applying a cooling element to a local adipose tissue deposit, wherein the cooling element cools the local adipose tissue deposit to a temperature of between 0° C. to 30° C. for a period of time sufficient to induce browning of adipose tissue in one or more areas of the subject's body remote to the local adipose tissue deposit.
Claims23
A method of inducing remote browning of adipose tissue in a subject comprising carrying out a plurality of treatments on the subject wherein the treatments comprise at least a first treatment and a second treatment, wherein the first treatment comprises cooling a first local adipose tissue deposit to a temperature of between 0° C. to 30° C. for a first period of time sufficient to induce browning of adipose tissue in one or more areas of the subject's body remote to the first local adipose tissue deposit;
- and wherein the second treatment comprises cooling a second local adipose tissue deposit to a temperature of 0° C. to 30° C. for a second period of time sufficient to induce browning of adipose tissue in one or more areas of the subject's body remote to the second local adipose tissue deposit;
- wherein the first and second local adipose tissue deposits are the same or are different;
- and
- wherein the second treatment is carried out 2-30 days after the day that the first treatment is carried out.
Dependencies are inferred from the claim text.