# US 12,119,100 B2 · Intelligent medication delivery systems and methods for medicine dose calculation and reporting

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- Number: US 12,119,100 B2
- Document ID: US12119100B2
- Status: Granted
- Kind: B2
- Application number: 18/104,473
- Filed: 2023-02-01
- Published: 2023-06-22
- Granted: 2024-10-15
- Earliest claimed: 2018-06-20
- Assignees: Medtronic MiniMed, Inc.
- Applicants: Medtronic MiniMed, Inc.
- Inventors: Michael Mensinger; Sean Saint
- Web page: https://patentgrep.com/patent/US12119100B2

## CPC

- G16H 20/17: delivered via infusion or injection
- A61M 5/009: {Electronic or electro-mechanical add-on modules}
- A61M 5/1723: {using feedback of body parameters, e.g. blood sugar or pressure}
- A61M 5/24: Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
- A61M 5/2422: {using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule}
- A61M 5/31551: {including axial movement of dose setting member}
- A61M 5/31553: {without axial movement of dose setting member}
- A61M 5/31568: {Means keeping track of the total dose administered, e.g. since the cartridge was inserted}
- G16H 15/00: ICT specially adapted for medical reports, e.g. generation or transmission thereof
- G16H 40/63: for local operation
- G16H 40/67: for remote operation
- G16H 50/70: for mining of medical data, e.g. analysing previous cases of other patients
- A61M 5/31546: {Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons}
- A61M 2005/3126: {related to dosing}
- A61M 2005/31588: {electrically driven}
- A61M 2205/3561: local, e.g. within room or hospital
- A61M 2205/3584: using modem, internet or Bluetooth®
- A61M 2205/3592: using telemetric means, e.g. radio or optical transmission
- A61M 2205/50: with microprocessors or computers
- A61M 2205/502: User interfaces, e.g. screens or keyboards
- A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient
- A61M 2205/583: by visual feedback
- A61M 2230/06: Heartbeat rate only
- A61M 2230/201: Glucose concentration
- A61M 2230/30: Blood pressure (A61M2230/04 takes precedence)
- A61M 2230/63: Motion, e.g. physical activity
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

Systems, devices, and techniques are disclosed for administering and tracking medicine to patients and providing health management capabilities for patients and caregivers. In some aspects, a system includes an injection pen device in communication with a mobile communication device having a software application to determine a recommended dose based on prior dose data, analyte data, and nutrient data and to generate a report illustrative of a relationship between the medicine data, the health data, and the contextual data.

## Claims

### Claim 1

A system, comprising: one or more processors; and one or more processor-readable media storing instructions which, when executed by the one or more processors, cause performance of: receiving, from an injection pen device, dose data associated with a dispensing of a dose of medicine from the injection pen device; receiving analyte data associated with a user of the injection pen device; determining a recommended dose of medicine to be administered to the user of the injection pen device based on the dose data received from the injection pen device and the analyte data associated with the user of the injection pen device; displaying an indication of a missed dose on a value-time plot of the analyte data; and displaying a graphical representation, separate from the indication of the missed dose, depicting a total number of missed doses, a dose type associated with the missed doses, and an indication of a time of day at which the missed doses occurred.

### Claim 2 (depends on 1)

The system according to claim 1, wherein the one or more processor-readable media further store instructions which, when executed by the one or more processors, cause performance of: displaying a value-time plot of the dose data such that a time axis of the value-time plot of the dose data is vertically aligned with a time axis of the value-time plot of the analyte data.

### Claim 3 (depends on 1)

The system according to claim 1, wherein the one or more processor-readable media further store instructions which, when executed by the one or more processors, cause performance of: displaying the recommended dose of medicine.

### Claim 4 (depends on 3)

The system according to claim 3, wherein the one or more processor-readable media further store instructions which, when executed by the one or more processors, cause performance of: modifying the recommended dose of medicine in response to a determination that the recommended dose of medicine was not administered to the user of the injection pen device within a predetermined time period initiated by the displaying of the recommended dose of medicine.

### Claim 5 (depends on 1)

The system according to claim 1, wherein the one or more processor-readable media further store instructions which, when executed by the one or more processors, cause performance of: determining the recommended dose of medicine based on contextual data associated with the user of the injection pen device.

### Claim 6 (depends on 5)

The system according to claim 5, wherein the one or more processor-readable media further store instructions which, when executed by the one or more processors, cause performance of: simultaneously displaying the value-time plot of the analyte data, a value-time plot of the dose data, and a value-time plot of the contextual data, wherein each of the value-time plots has a time axis that is displayed in vertical alignment with a time axis of the other value-time plots.

### Claim 7 (depends on 1)

The tangible non-transitory computer readable medium of claim 1, wherein the reference ontology is based at least in part on a plurality of clinical reports relevant to a plurality of clinical pathways.

### Claim 8 (depends on 1)

The tangible non-transitory computer readable medium of claim 1, wherein the deviation rules comprise temporal constraints, sequential constraints, volumetric constraints, and/or professional role constraints.

### Claim 9

A system, comprising: an injection pen device configured to administer medicine to a patient; and a software application installable on a mobile communication device in communication with the injection pen device, the mobile communication device having one or more processors and one or more processor-readable media storing the software application which, when executed by the one or more processors, causes performance of: receiving, from the injection pen device, dose data associated with a dispensing of a dose of medicine from the injection pen device; determining a recommended dose of the medicine based on the dose data received from the injection pen device and analyte data associated with a user of the injection pen device; displaying an indication of a missed dose displayed on a value-time plot of the analyte data; and displaying a graphical representation, separate from the indication of the missed dose, depicting a total number of missed doses, a dose type associated with the missed doses, and an indication of a time of day at which the missed doses occurred.

### Claim 10 (depends on 9)

The system according to claim 9, wherein the software application, when executed by the one or more processors, further causes performance of: displaying a value-time plot of the dose data such that a time axis of the value-time plot of the dose data is vertically aligned with a time axis of the value-time plot of the analyte data.

### Claim 11 (depends on 9)

The system according to claim 9, wherein the software application, when executed by the one or more processors, further causes performance of: displaying the recommended dose of medicine.

### Claim 12 (depends on 11)

The system according to claim 11, wherein the software application, when executed by the one or more processors, further causes performance of: modifying the recommended dose of medicine in response to a determination that the recommended dose of medicine was not administered by the injection pen device within a predetermined time period initiated by the displaying of the recommended dose of medicine.

### Claim 13 (depends on 9)

The system according to claim 9, wherein the software application, when executed by the one or more processors, further causes performance of: displaying the indication of the missed dose on the value-time plot of the analyte data at a time along a time axis of the value-time plot of the analyte data by which the recommended dose of medicine should have been administered to the user of the injection pen device.

### Claim 14

One or more non-transitory processor readable media storing instructions which, when executed by one or more processors, cause performance of: receiving, from an injection pen device, dose data associated with a dispensing of a dose of medicine from the injection pen device; receiving analyte data associated with a user of the injection pen device; determining a recommended dose of the medicine based on the dose data received from the injection pen device and the analyte data associated with the user of the injection pen device; displaying an indication of a missed dose displayed on a value-time plot representing the analyte data; and displaying a graphical representation, separate from the indication of the missed dose, depicting a total number of missed doses, a dose type associated with the missed doses, and an indication of a time of day at which the missed doses occurred.

### Claim 15 (depends on 14)

The one or more non-transitory processor-readable media according to claim 14, wherein the one or more non-transitory processor-readable media store further instructions which, when executed by the one or more processors, cause performance of: displaying a value-time plot of the dose data such that a time axis of the value-time plot of the dose data is vertically aligned with a time axis of the value-time plot of the analyte data.

### Claim 16 (depends on 14)

The one or more non-transitory processor-readable media according to claim 14, wherein the one or more non-transitory processor-readable media store further instructions which, when executed by the one or more processors, cause performance of: displaying the recommended dose of medicine.

### Claim 17 (depends on 14)

The one or more non-transitory processor-readable media according to claim 14, wherein the one or more non-transitory processor-readable media store further instructions which, when executed by the one or more processors, cause performance of: modifying the recommended dose of medicine in response to a determination that the recommended dose of medicine was not administered to the user of the injection pen device within a predetermined time period initiated by the displaying of the recommended dose of medicine.