# US 12,118,896 B2 · Visual bionic digestive system for human gastrointestinal tract model

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- Number: US 12,118,896 B2
- Document ID: US12118896B2
- Status: Granted
- Kind: B2
- Application number: 16/121,720
- Filed: 2018-09-05
- Published: 2019-07-25
- Granted: 2024-10-15
- Earliest claimed: 2018-01-24
- Assignees: Jiangnan University
- Applicants: Jiangnan University
- Inventors: Xiaobei Zhan; Zhitao Li; Minjie Gao; Wenlong Zhang; Zhiyong Zheng; Xingqiao Peng; Yun Jiang
- Web page: https://patentgrep.com/patent/US12118896B2

## CPC

- G09B 23/32: with moving parts
- B01L 3/5085: {for multiple samples, e.g. microtitration plates}
- B01L 3/561: {Tubes; Conduits}
- B01L 3/567: {Valves, taps or stop-cocks}
- G01N 33/00: Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G09B 23/303: {specially adapted to simulate circulation of bodily fluids}
- B01L 2200/06: Fluid handling related problems
- B01L 2300/049: Valves integrated in closure
- B01L 2300/08: Geometry, shape and general structure
- B01L 2300/0832: cylindrical, tube shaped
- B01L 2300/0874: Three dimensional network
- B01L 2400/0666: Solenoid valves
- G01N 33/02: Food
- G09B: EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS (devices for psychotechnics or for testing reaction times A61B5/16; games, sports, amusements A63; projectors, projector screens G03B)
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present invention discloses a visual bionic digestive system for a human gastrointestinal tract model, and belongs to the field of bionic digestive systems. The visual bionic digestive system for a human gastrointestinal tract model comprises a reaction system and a control system; the reaction system comprises a bionic stomach system, a bionic small intestine system, a bionic large intestine system and a filtering system; the control system comprises a PLC, peristaltic pumps, and a circulating water tank; the water inlet pipes of the bionic stomach system, the bionic small intestine system, and the bionic large intestine system are connected to a water outlet of the circulating water tank through water pipes; the water outlet pipes of the bionic stomach system, the bionic small intestine system, and the bionic large intestine system are connected to a water inlet of the circulating water tank through water pipes, solenoid valves are arranged on the water pipes, and the solenoid valves on the water pipes are controlled by the PLC. The bionic digestive system provided by the present invention has the advantages of strong visibility, high automation, device modularization, and simple and effective gastrointestinal peristalsis simulation way.

## Claims

### Claim 1

A system comprising a reaction system and a control system,
wherein the reaction system comprises a bionic stomach system, a bionic small intestine system, and a bionic large intestine system;
wherein the control system comprises a Programmable Logic Controller (PLC), peristaltic pumps, and a circulating water tank;
wherein the bionic stomach system, the bionic small intestine system, and the bionic large intestine system each comprise water inlet pipes and water outlet pipes;
wherein the water inlet pipes of the bionic stomach system, the bionic small intestine system, and the bionic large intestine system are connected to a water outlet of the circulating water tank;
wherein the water outlet pipes of the bionic stomach system, the bionic small intestine system, and the bionic large intestine system are connected to a water inlet of the circulating water tank;
wherein the PLC is configured to control flow between the circulating water tank and the bionic stomach system, the bionic small intestine system, and the bionic large intestine system;
wherein the bionic stomach system, the bionic small intestine system, the bionic large intestine system or any combination thereof comprises a bionic gastrointestinal tract inside a reactor;
wherein a space between the bionic gastrointestinal tract and the reactor is configured to accommodate water circulating between the circulating water tank and the bionic stomach system; and
wherein the PLC is configured to cause a reciprocating motion of a sample inside the bionic gastrointestinal tract by varying a pressure of the water.

### Claim 2 (depends on 1)

The system according to claim 1, further comprising a sample delivery device;
wherein the sample delivery device comprises a first gas bottle and a plurality of sample bottles;
wherein the plurality of sample bottles is connected to the bionic stomach system through the peristaltic pumps;
wherein one opening of the first gas bottle is communicated with one of the plurality of sample bottles, and another opening is connected to the bionic stomach system.

### Claim 3 (depends on 1)

The system according to claim 1, wherein that the bionic stomach system comprises a first adapter, a first cylindrical reactor, a spherical reactor, a first sampler, a second cylindrical reactor, and a second adapter serially connected by flanges;
wherein the bionic stomach system is configured to receive a sample from the first adapter and configured to output the sample from the second adapter;
wherein the second adapter is connected to the bionic small intestine system through the peristaltic pumps.

### Claim 4 (depends on 1)

The system according to claim 1, wherein the bionic small intestine system comprises a third adapter, a third cylindrical reactor, a second sampler, a fourth cylindrical reactor, and a fourth adapter serially connected by flanges;
wherein the second sampler comprises a lower end opening and a syringe pump, the third adapter is connected to a digestive juice bottle through the peristaltic pumps, and the digestive juice bottle is communicated with a second gas bottle.

### Claim 5 (depends on 1)

The system according to claim 1, wherein the bionic large intestine system comprises a fifth adapter, a fifth cylindrical reactor, a third sampler, a sixth cylindrical reactor, and a sixth adapter serially connected by flanges;
wherein the fifth adapter is connected to the lower end opening of the second sampler through the peristaltic pumps, and the third sampler comprises a lower end opening.

### Claim 6 (depends on 1)

The system according to claim 1, further comprises a filter connected to a fourth adapter of the bionic small intestine system.

### Claim 7 (depends on 1)

The system according to claim 1, wherein the first sampler of the bionic stomach system, the second sampler of the bionic small intestine system and the third sampler of the bionic large intestine system each comprise two glass tubes configured to receive pH electrode probes and microscope probes.

### Claim 8 (depends on 4)

The system according to claim 4, wherein the PLC is configured to control the peristaltic pumps and the syringe pumps.

### Claim 9 (depends on 2)

The system according to claim 2, wherein the first gas bottle is configured to be filled with a mixed gas of N2 and CO2.

### Claim 10 (depends on 7)

The system according to claim 7, wherein the third sampler comprises an inoculation port configured for inoculating the large intestine system with intestinal microorganisms.