Methods for treating polymicrobial infections
AssigneeCap Diagnostics, LLC
InventorsDavid A. Baunoch, Miguel F. R. Penaranda, Michael L. Opel, Maher Badir, Natalie Luke
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Abstract
Methods for detecting and treating polymicrobial infections, wherein a mixed population of microbes (e.g., bacteria) are present in a patient sample and the microbes are not first isolated from the sample. For example, the present invention describes specific polymicrobial infections and methods of treating said infections, wherein a particular antibiotic or a group of antibiotics are selected based on the composition of the polymicrobial infections.
Claims2
A method for treating a patient having or suspected of having a polymicrobial infection comprising a combination of Escherichia coli (E. coli) and Proteus mirabilis (P. mirabilis), the method comprising:
- a. detecting the presence of both E. coli and P. mirabilis in a source of the infection obtained from the patient;
- and
- b. administering to the patient a therapeutically effective amount of a composition comprising an antibiotic selected from the group consisting of:
- (i) cefaclor;
- (ii) cefazolin;
- (iii) cefoxitin;
- (iv) ceftazidime;
- and (v) ceftriaxone;
- wherein the E. coli and P. mirabilis together have a decreased odds of resistance to cefaclor, cefazolin, cefoxitin, ceftazidime, and ceftriaxone, thus cefaclor, cefazolin, cefoxitin, ceftazidime, and ceftriaxone are effective for killing or inhibiting growth of the E. coli and P. mirabilis to treat the polymicrobial infection.
Dependencies are inferred from the claim text.