Compositions and methods related to fungal hypoxia responsive morphology factor a (hrmA) and biofilm architecture factor (baf) proteins
AssigneeTrustees of Dartmouth College
InventorsRobert A. Cramer, Jr., Caitlin Kowalski
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Abstract
Filamentous fungal host cells expressing hypoxia responsive morphology factor A (hrmA) and biofilm architecture factor (baf) proteins are provided. Methods of producing filamentous fungal host cells expressing hrmA and baf proteins are also provided. In one aspect, the disclosure provides a filamentous fungal host cell, comprising a nucleotide sequence encoding an Aspergillus fumigatus hypoxia responsive morphology factor A (hrmA) protein, or a homolog or ortholog thereof.
Claims7
A filamentous fungal host cell, comprising an exogenous nucleotide sequence encoding an Aspergillus fumigatus biofilm architecture factor (baf) protein, wherein the baf protein comprises (a) bafA, or a homolog or ortholog thereof having bafA activity, (b) bafB, or a homolog or ortholog thereof having bafB activity, and (c) bafC, or a homolog or ortholog thereof having bafC activity, the bafA protein or a homolog or ortholog thereof having bafA activity comprising at least 90% identity to the amino acid sequence of SEQ ID NO:
- 13;
- the bafB protein or a homolog or ortholog thereof having bafB activity comprising at least 90% identity to the amino acid sequence of SEQ ID NO:
- 14;
- and the bafC protein or a homolog or ortholog thereof having bafC activity comprising at least 90% identity to the amino acid sequence of SEQ ID NO:
- 15.
Dependencies are inferred from the claim text.