Host-guest interactions for pa superstructure formation
AssigneeNorthwestern University
InventorsSamuel I. Stupp, Alexandra N. Kolberg, Tristan D. Clemons, Stacey M. Chin
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Abstract
The disclosure relates to compositions and superstructures comprising peptide amphiphiles. In some aspects, the disclosure relates to compositions and superstructures comprising host and guest peptide amphiphiles, wherein the host and guest moieties of the peptide amphiphiles interact via non-covalent interactions to form a supramolecular assembly, such a superstructure. In some aspects, the superstructure further comprises a bioactive moiety. Suitable bioactive moieties may be selected to promote cell growth, migration, and/or differentiation.
Claims6
A composition comprising:
- a. one or more host peptide amphiphiles comprising a hydrophobic segment comprising an 8-24 carbon alkyl chain (C8-24), a structural peptide segment comprising V2A2, a charged peptide segment comprising E4, and a host moiety comprising β-cyclodextrin;
- and
- b. one or more guest peptide amphiphiles comprising a hydrophobic segment comprising an 8-24 carbon alkyl chain (C8-24), a structural peptide segment comprising V2A2, a charged peptide segment comprising E4, and a guest moiety comprising adamantane;
- and
- c. one or more diluent peptide amphiphiles, wherein each of the one or more diluent peptide amphiphiles comprises a hydrophobic segment comprising an 8-24 carbon alkyl chain (C8-24), a structural peptide segment, and a charged peptide segment, and does not comprise a host moiety or a guest moiety,
- wherein the host moiety and the guest moiety interact non-covalently to form a host-guest complex within the composition.
Dependencies are inferred from the claim text.