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US 12,116,458 B2Granted
Cationic polymer with alkyl side chains and use for biomolecule delivery
AssigneeGenEdit Inc.
InventorsKunwoo Lee, Santanu Maity
Life of this patent
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Abstract
Provided is a polymer comprising a structure of Formula 1 or Formula 3 as provided herein, as well as a method of making the same; a composition comprising the polymer and a nucleic acid and/or polypeptide; and a method of delivering a nucleic acid and/or polypeptide to a cell.
Claims20
A polymer comprising a structure of Formula 1:
- wherein,
- m1 is an integer from 1 to 2000;
- R1 is a methylene or ethylene group;
- R14 is hydrogen or a C1-C12 alkyl group, alkenyl group, cycloalkyl group, or cycloalkenyl group;
- X is a C1-C12 alkyl group, cycloalkyl group, alkenyl group, cycloalkenyl group, aryl group, heteroalkyl group, or heterocyclic group;
- A1 is a group of formula
- —(CH2)p1—[NR2—(CH2)q1—]r1NR22;
- —(CH2)p2—N[—(CH2)q2—NR22]2;
- —(CH2)p3—N{[—(CH2)q3—NR22][—(CH2)q4—NR2—]r2R2};
- or
- —(CH2)p4—N{—(CH2)q5—N[—(CH2)q6—NR22]2}2,
- wherein p1 to p4, q1 to q6, and r1 and r2 are each independently an integer of 1 to 5;
- and
- each instance of R2 is independently hydrogen or a C1-C12 alkyl group, alkenyl group, cycloalkyl group, or cycloalkenyl group.
11 more elements
A polymer comprising a structure of Formula 3:
- wherein,
- each of m1 and n1 is an integer from 0 to 1000;
- provided that the sum of m1+n1 is greater than 5;
- the symbol “/” indicates that the units separated thereby are linked randomly or in any order;
- R1 and R3 each independently are a methylene or ethylene group;
- each instance of R14 is independently hydrogen or a C1-C12 alkyl group, alkenyl group, cycloalkyl group, or cycloalkenyl group;
- each instance of X is independently a C1-C12 alkyl group, cycloalkyl group, alkenyl group, cycloalkenyl group, aryl group, heteroalkyl group, or heterocyclic group;
- A1 and A2 are each independently a group of formula
- —(CH2)p1—[NR2—(CH2)q1—]r1NR22;
- —(CH2)p2—N[—(CH2)q2—NR22]2;
- —(CH2)p3—N{[—(CH2)q3—NR22][—(CH2)q4—NR2—]r2R2};
- or
- —(CH2)p4—N{—(CH2)q5—N[—(CH2)q6—NR22]2}2,
- wherein p1 to p4, q1 to q6, and r1 and r2 are each independently an integer of 1 to 5;
- and
- each instance of R2 is independently hydrogen or a C1-C12 alkyl group, alkenyl group, cycloalkyl group, or cycloalkenyl group.
13 more elements
Dependencies are inferred from the claim text.