Antimicrobial peptides
AssigneeThe Trustees of the University of Pennsylvania
InventorsMarcelo Der Torossian Torres, Cesar de la Fuente-Nunez, Gislaine G. O. Silva, Octavio L Franco
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Abstract
Provided herein are synthetic peptides with enhanced antimicrobial and antibiofilm characteristics, and are biocompatible with mammalian cellular systems. The disclosed synthetic antimicrobial moieties include a mastoparan peptide having SEQ ID NO:1 and a pentapeptide motif formed from phenylalanine, leucine, proline, and two isoleucine residues, wherein the pentapeptide motif is conjugated the N-terminus of the mastoparan peptide. Also provided are compositions comprising the synthetic peptides, as well as methods of treating a microbial infection or removing a biofilm using the peptides.
Claims22
An antimicrobial peptide that comprises a mastoparan peptide having SEQ ID NO:1 and a pentapeptide motif formed from phenylalanine, leucine, proline, and two isoleucine residues, wherein the pentapeptide motif is conjugated the N-terminus of the mastoparan peptide, wherein the antimicrobial peptide is not SEQ ID NO:5.
A method of forming an antimicrobial peptide comprising conjugating a pentapeptide motif formed from phenylalanine, leucine, proline, and two isoleucine residues to a mastoparan peptide having SEQ ID NO:1 at the N-terminus of the peptide, wherein the pentapeptide motif is not FLPII.
Dependencies are inferred from the claim text.