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US 12,116,367 B2Granted
Ring-modified proline short peptide compound and use thereof
AssigneeFujian Akeylink Biotechnology Co., Ltd.
InventorsShuhui Chen, Yaxun Yang, Jianchen Zhang, Peng Li, Haiying He, Zheng Wang, Jian Li
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Abstract
Disclosed are a ring-modified proline short peptide compound and the use thereof, and specifically disclosed is a compound represented by formula (X) or a pharmaceutically acceptable salt thereof.
Claims8
A compound represented by formula (I″) or a pharmaceutically acceptable salt thereof,
- wherein,
- R5 is selected from C1-3 haloalkyl;
- the structural moiety
- and the
- is optionally and independently substituted by 1, 2 or 3 Ra′;
- ring D is selected from C4-8 cycloalkyl, C5-8 cycloalkenyl and 5- to 8-membered heterocycloalkyl, and the C4-8 cycloalkyl is optionally substituted by 1 or 2 Ra′;
- Ra′ is each independently selected from F and methyl;
- the heterocycloalkyl contains 1, 2 or 3 heteroatoms or heteroatom groups independently selected from O, S, N and NH.
5 more elements
Dependencies are inferred from the claim text.