Hydrocortisone acetate suppository formulation for treatment of disease

A method of delivering a formulation to the rectum of a subject in need thereof, comprising rectally administering a formulation comprising about 0.5% to about 5% by weight hydrocortisone acetate, about 0.1% to about 5% by weight colloidal silicon dioxide, a semi-synthetic glyceride base comprising saturated C8-C18 triglyceride fatty acids, and lecithin to the subject, wherein the formulation has a melting temperature in the range of about 37° C. to about 39° C. and wherein the subject in need thereof has a gastrointestinal disease selected from ulcerative colitis or Crohn's disease.