US 12,115,178 B2 · Acylated active agents and methods of their use for the treatment of autoimmune disorders

Acylated active agents and methods of their use for the treatment of autoimmune disorders

AssigneeFlagship Pioneering Innovations V, Inc.

InventorsSteven John Taylor, Mi-Jeong Kim, Kathleen Nudel, Timothy F. Briggs, Koji Yasuda, Leonard Buckbinder, Bernard Lanter, Spencer Cory Peck, Cheri Snedeker, Angela She, Jessica Alexander, Anna Liang, Jenny Liu, Dinara Gunasekera, David Arthur Berry, John Patrick Casey, Jr., Amir H. Moarefi

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Abstract

Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.

Claims9

Dependent claims

A method of modulating an autoimmunity marker in a subject, the method comprising administering to the subject an effective amount of a compound of the structure:

or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

17/557,772Filed 21 Dec 2021 · division

Priority

5 Jun 2018

Published

US 2022/0110960 A114 Apr 2022

Granted

15 Oct 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification25 codes

A61K 31/7036
Attached to a carbocyclic compound, e.g. phloridzin: having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin,…
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration
A61K 31/191
Carboxylic acids, e.g. valproic acid: having two or more hydroxy groups, e.g. gluconic acid
A61K 31/196
Having an amino group: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil

Family

Application62/680,965Us provisional application · filed 5 Jun 2018

Application62/776,377Us provisional application · filed 6 Dec 2018

PCT/US2019/035677Parent of this continuation · filed 5 Jun 2019

Application16/803,284Parent of this continuation · filed 27 Feb 2020

Application17/319,285Parent of this division · filed 13 May 2021

US 11,058,698 B2Parent of this continuation · filed 13 Jul 2021

US 2022/0110960 A1Pre-grant publication · published 14 Apr 2022

Application17/319,285Parent of this continuation

US 2020/0188418 A1Published application

US 2021/0283157 A1Published application

US 12,115,178 B2This patent

From the US filing history. Foreign family members aren’t listed.