# US 12,112,933 B2 · Imaging mass spectrometer > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,112,933 B2 - Document ID: US12112933B2 - Status: Granted - Kind: B2 - Application number: 17/628,969 - Filed: 2019-08-01 - Published: 2022-08-18 - Granted: 2024-10-08 - Earliest claimed: 2019-08-01 - Assignees: Shimadzu Corporation - Applicants: Shimadzu Corporation - Inventors: Kengo Takeshita - Web page: https://patentgrep.com/patent/US12112933B2 ## CPC - H01J 49/0036: {Step by step routines describing the handling of the data generated during a measurement} - G01N 27/62: by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode - H01J 49/0004: {Imaging particle spectrometry} - G06F 2218/14: by matching peak patterns - H01J: ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS (spark-gaps H01T; electric arc lamps H05B31/00; particle accelerators H05H) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - G06F: ELECTRIC DIGITAL DATA PROCESSING (computer systems based on specific computational models G06N) ## Abstract An imaging mass spectrometer according to one mode of the present invention includes: an analysis execution section (1, 31) configured to perform a mass spectrometric analysis on each of a plurality of measurement points set within a two-dimensional area on a sample, to collect mass spectrum data over a predetermined mass-to-charge-ratio range for each measurement point; a condition memory section (32) configured to store a data matrix creation condition to be used for creation of a data matrix based on the mass spectrum data acquired by the analysis in the analysis execution section; and a data matrix creation section (42) configured to begin, in the middle of an execution of the analysis by the analysis execution section or subsequently to the completion of the analysis, the creation of the data matrix based on mass spectrum data already collected until then, according to the data matrix creation condition stored in the condition memory section. ## Claims ### Claim 1 An imaging mass spectrometer, comprising: an analysis execution section configured to perform a mass spectrometric analysis on each of a plurality of measurement points set within a two-dimensional area on a sample, to collect mass spectrum data over a predetermined mass-to-charge-ratio range for each measurement point; a condition memory section configured to store a data matrix creation condition to be used for creation of a data matrix based on the mass spectrum data acquired by the analysis in the analysis execution section; and a data matrix creation section configured to begin, in a middle of an execution of the analysis by the analysis execution section, the creation of the data matrix based on mass spectrum data already collected until then, according to the data matrix creation condition stored in the condition memory section. ### Claim 2 (depends on 1) The imaging mass spectrometer according to claim 1, further comprising a multivariate analysis processing section configured to perform a multivariate analysis using the data matrix created by the data matrix creation section. ### Claim 3 (depends on 1) The imaging mass spectrometer according to claim 1, further comprising a condition-setting section configured to allow a user to set the data matrix creation condition before the execution of the analysis by the analysis execution section, and to store the set data matrix creation condition in the condition memory section. ### Claim 4 (depends on 3) The imaging mass spectrometer according to claim 3, wherein the condition-setting section is configured to allow a user to set the data matrix creation condition along with an analysis condition for the analysis by the analysis execution section. ### Claim 5 (depends on 1) The imaging mass spectrometer according to claim 1, wherein the data matrix creation condition includes a requirement that the data matrix be created for mass-to-charge ratios described in a list of target substances. ### Claim 6 (depends on 1) The imaging mass spectrometer according to claim 1, wherein the data matrix creation condition includes a requirement that the data matrix be created for mass-to-charge ratios corresponding to peaks in an average mass spectrum or maximum intensity mass spectrum calculated based on all mass spectrum data collected. ### Claim 7 (depends on 1) The imaging mass spectrometer according to claim 1, wherein a timing to store the data matrix creation condition in the condition memory section is earlier than the execution of the analysis by the analysis execution section. ### Claim 8 An imaging mass spectrometer, comprising: an analysis execution section configured to perform a mass spectrometric analysis on each of a plurality of measurement points set within a two-dimensional area on a sample, to collect mass spectrum data over a predetermined mass-to-charge-ratio range for each measurement point; a condition memory section configured to store a data matrix creation condition to be used for creation of a data matrix based on the mass spectrum data acquired by the analysis in the analysis execution section; and a data matrix creation section configured to begin, in a middle of an execution of the analysis by the analysis execution section or in response to completion of the analysis, the creation of the data matrix based on mass spectrum data already collected until then, according to the data matrix creation condition stored in the condition memory section, wherein the data matrix creation section is further configured to switch a point in time to begin the creation of the data matrix between a point in time in the middle of the execution of the analysis by the analysis execution section and a point in time immediately after the analysis, depending on the data matrix creation condition.