# US 12,112,853 B2 · Method for assisting with prognosis

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- Number: US 12,112,853 B2
- Document ID: US12112853B2
- Status: Granted
- Kind: B2
- Application number: 17/611,997
- Filed: 2020-05-29
- Published: 2023-07-06
- Granted: 2024-10-08
- Earliest claimed: 2019-05-31
- Assignees: Inserm (Institut National De La Sante Et De La Recherche Medicale); Commissariat A L'energie Atomique Et Aux Energies Alternatives; University Paris-Saclay; Centre National de la Recherche Scientifique (CNRS)
- Applicants: Inserm (Institut National De La Santé Et De La Recherche MéDicale); Commissariat A L'energie Atomique Et Aux Energies Alternatives; Universite Paris-Saclay; Centre National De La Recherche Scientifique—Cnrs—
- Inventors: Irène Buvat
- Web page: https://patentgrep.com/patent/US12112853B2

## CPC

- G16H 30/40: for processing medical images, e.g. editing
- G16H 50/30: for calculating health indices; for individual health risk assessment
- G06T 7/0014: {using an image reference approach}
- G16H 20/10: relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems
- G06T 2207/10104: Positron emission tomography [PET]
- G06T 2207/30096: Tumor; Lesion
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL

## Abstract

The present invention relates to a method for assisting with lymphoma prognosis. The prognosis of therapeutic response of patients with lymphoma is difficult. Based on a study of advanced stage DLBCL patients, the inventors showed that medical imaging such as 18F-FDG-PET/CT can provide a prognostic radiomic signature combining metrics reflecting tumor dissemination and tumor burden. In another aspect, the invention relates to a computer software comprising instructions to implement at least a part of a method according to the invention. In yet another aspect, the invention relates to a computer-readable non-transient recording medium on which a software is registered to implement a method according to the invention.

## Claims

### Claim 1

A computer implemented method for assisting with lymphoma prognosis comprising:
providing imaging data of a patient presenting a lymphoma,
segmenting the imaging data so as to identify lesions, wherein the segmentation further comprises erasing regions with a naturally high concentration of a tracing agent,
determining a distance between the two lesions which are furthest apart,
determining the metabolic tumor volume, and
providing a prognosis indicator based on the distance between the two lesions which are furthest apart and on the metabolic tumor volume.

### Claim 2 (depends on 1)

Method according to claim 1, wherein the provided imaging data are PET scan data.

### Claim 3 (depends on 1)

Method according to claim 1, wherein the segmentation is based on a concentration of the tracing agent.

### Claim 4 (depends on 1)

Method according to claim 1, further comprising a step comprising providing help with the decisions between several medical treatments based on the prognosis indicator.

### Claim 5 (depends on 4)

Method according to claim 4, wherein the several medical treatments comprise an RCHOP-type treatment and an RACVBP-type treatment.

### Claim 6 (depends on 1)

Computer software comprising instructions to implement at least a part of a method according to claim 1 when the software is executed by a processor.

### Claim 7 (depends on 1)

Computer-readable non-transient recording medium on which a software is registered to implement a method according to claim 1 when the software is executed by a processor.