# US 12,111,289 B2 · Systems and methods for imaging cortical bone and soft tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,111,289 B2 - Document ID: US12111289B2 - Status: Granted - Kind: B2 - Application number: 17/255,410 - Filed: 2019-06-26 - Published: 2021-07-15 - Granted: 2024-10-08 - Earliest claimed: 2018-06-26 - Assignees: Massachusetts Institute of Technology - Applicants: Massachusetts Institute of Technology - Inventors: Jonathan Randall Fincke; Brian W. Anthony - Web page: https://patentgrep.com/patent/US12111289B2 ## CPC - A61B 8/0808: {for diagnosis of the brain} - G01N 29/0672: {by acoustic tomography (medical tomography A61B8/13)} - A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging - A61B 8/5223: {for extracting a diagnostic or physiological parameter from medical diagnostic data (for algorithms to analyse biomedical images G06T7/0012)} - G01N 21/1702: {with opto-acoustic detection, e.g. for gases or analysing solids} - G01N 29/2418: {using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics (photoacoustic cells G01N21/1702; measuring characteristics of vibrations by using radiation-sensitive means G01H9/00; acousto-optical conversion techniques for short-range imaging G01S15/8965; sound-producing devices using laser bundle G10K15/046)} - G01N 33/12: Meat; Fish - A61B 5/0095: {by applying light and detecting acoustic waves, i.e. photoacoustic measurements} - A61B 8/13: Tomography (A61B8/10, A61B8/12 take precedence) - A61F 2/76: Means for assembling, fitting or testing prostheses, e.g. for measuring or balancing - G01N 2021/1706: {in solids} - G01N 2291/02475: Tissue characterisation - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract Systems and methods are provided for imaging of soft and hard tissues with ultrasound. Such systems and methods can provide for non-contact and quantitative ultrasound images of bone and soft tissue. A method for imaging a biological body segment of soft and hard tissues includes setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set. The method further includes collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set and minimizing a difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment. Regularizing travel-time and/or using full waveform tomographic techniques with level set methods enable recovery of cortical bone geometry. ## Claims ### Claim 1 A method for imaging a biological body segment of soft and hard tissues, comprising: a) setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set, wherein generating simulated time series data employs at least one tissue boundary detection process; b) collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set of images of the biological body segment; and c) minimizing the difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment. ### Claim 2 (depends on 1) The method of claim 1, wherein the reflective and transmissive time series data is collected by employing an ultrasound transducer that emits an ultrasound beam of known beam geometry for reflection and transmission at the biological body segment. ### Claim 3 (depends on 1) The method of claim 1, further including modifying the model, modifying the simulated time series data, or modifying both the model and the simulated time series data to more accurately emulate experimental time series data. ### Claim 4 (depends on 1) The method of claim 1, further including modifying the model by at least one of the following: including prior information about biological tissue being imaged; including prior information about a motion trajectory of one or more transducers employed in collecting the reflective and transmissive time series data; including a model of a motion trajectory of one or more transducers employed in collecting the reflective and transmissive time series data; including prior information about a response of one or more transducers employed in collecting the reflective and transmissive time series data; and including a model of a response of one or more transducers employed in collecting the reflective and transmissive time series data. ### Claim 5 (depends on 1) The method of claim 1, including applying a level set technique including a full waveform inversion. ### Claim 6 (depends on 1) The method of claim 1, wherein collecting the reflective and transmissive time series data employs at least one of a water-immersed ultrasound transducer and a laser. ### Claim 7 (depends on 1) The method of claim 1, wherein minimizing the difference between the simulated time series data set and the experimental time series data set includes a full waveform inversion, a level set region segmentation of at least one portion or component of the biological body segment, a regularization of travel time or use of travel time to regularize full waveform inversion, or any combination thereof. ### Claim 8 (depends on 1) The method of claim 1, wherein collecting the reflective and transmissive time series data includes ultrasound tomography that employs a tank-based ultrasound system that includes at least two single-element transducers mounted at a tank of the tomography system, and further including the step of obtaining multi-aperture time series data from the single element transducers. ### Claim 9 A system for imaging a biological body segment of soft and hard tissues, comprising: at least one sensor configured to collect reflective and transmissive time series data of the biological body segment; and a processor configured to: generate a simulated time series data set based on geometry and material properties according to a model of the biological body segment, receive from the at least one sensor the collected reflective and transmissive time series data, generate an experimental time series data set from the collected reflective and transmissive time series data, and minimize a difference between the simulated time series data set and the experimental time series data set to thereby image the biological body segment. ### Claim 10 (depends on 9) The system of claim 9, further comprising an ultrasound transducer configured to emit an ultrasound beam of known beam geometry for reflection and transmission at the biological body segment. ### Claim 11 (depends on 9) The system of claim 9, wherein the processor is further configured to modify the model to more accurately emulate the experimental time series data. ### Claim 12 (depends on 9) The system of claim 9, wherein the processor is further configured to modify the model to include at least one of the following: prior information about biological tissue being imaged; prior information about a motion trajectory of one or more transducers employed in collecting the reflective and transmissive time series data; a model of a motion trajectory of one or more transducers employed in collecting the reflective and transmissive time series data; prior information about a response of one or more transducers employed in collecting the reflective and transmissive time series data; and a model of a response of one or more transducers employed in collecting the reflective and transmissive time series data. ### Claim 13 (depends on 9) The system of claim 9 wherein the processor is further configured to apply a level set technique including a full waveform inversion. ### Claim 14 (depends on 9) The system of claim 9, wherein the at least one sensor includes a water-immersed ultrasound transducer, one or more lasers, or a combination thereof. ### Claim 15 (depends on 9) The system of claim 9, wherein minimization of the difference between the simulated time series data set and the experimental time series data set includes a full waveform inversion, a level set region segmentation of at least one portion or component of the biological body segment, a regularization of travel time or use of travel time to regularize full waveform inversion, or any combination thereof. ### Claim 16 (depends on 9) The system of claim 9, wherein the system is a tank-based ultrasound tomography system that includes a tank and at least two single-element transducers mounted at a tank of the tomography system, and wherein collection of the reflective and transmissive time series data includes ultrasound tomography. ### Claim 17 (depends on 16) The system of claim 16, wherein the processor is further configured to obtain multi-aperture time series data from the single element transducers. ### Claim 18 (depends on 9) The system of claim 9, wherein the processor is further configured to apply at least one tissue boundary detection process for generation of the simulated time series data. ### Claim 19 A tank-based ultrasound computed tomography system, comprising: a) an immersion tank; b) at least one ultrasound transducer within the immersion tank that emits an ultrasound beam; c) at least one ultrasound receiver configured to detect reflection and transmission of the ultrasound beam following reflection and transmission of the ultrasound beam off or through a biological body segment; and a processor configured to: receive reflection and transmission data detected by the at least one ultrasound receiver, generate a simulated time series data set based on geometry and material properties according to a model of the biological body segment, generate an experimental time series data set from the received reflection and transmission data, and minimize a difference between the simulated time series data set and the experimental time series data set to thereby image the biological body segment. ### Claim 20 A method for imaging a biological body segment of soft and hard tissues, comprising: a) setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set; b) collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set of images of the biological body segment, wherein the reflective and transmissive time series data is collected by employing an ultrasound transducer that emits an ultrasound beam of known beam geometry for reflection and transmission at the biological body segment; and c) minimizing the difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment. ### Claim 21 A method for imaging a biological body segment of soft and hard tissues, comprising: a) setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set; b) collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set of images of the biological body segment, wherein collecting the reflective and transmissive time series data employs at least one of a water-immersed ultrasound transducer and a laser; and c) minimizing the difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment. ### Claim 22 A method for imaging a biological body segment of soft and hard tissues, comprising: a) setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set; b) collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set of images of the biological body segment, wherein collecting the reflective and transmissive time series data includes ultrasound tomography that employs a tank-based ultrasound system that includes at least two single-element transducers mounted at a tank of the tomography system, and further including the step of obtaining multi-aperture time series data from the single element transducers; and c) minimizing the difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment.