# US 12,110,970 B2 · Valve for transferring at least one fluid

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- Number: US 12,110,970 B2
- Document ID: US12110970B2
- Status: Granted
- Kind: B2
- Application number: 17/406,782
- Filed: 2021-08-19
- Published: 2021-12-09
- Granted: 2024-10-08
- Earliest claimed: 2019-02-20
- Assignees: Hoffmann-La Roche Inc.
- Applicants: Hoffmann-La Roche Inc.
- Inventors: Jennifer Römer; Christian Neusüss
- Web page: https://patentgrep.com/patent/US12110970B2

## CPC

- F16K 11/0743: {with both the supply and the discharge passages being on one side of the closure plates}
- F16K 31/041: {for rotating valves (F16K31/055 takes precedence)}
- G01N 30/20: using a sampling valve
- G01N 30/465: {with specially adapted interfaces between the columns}
- G01N 2030/202: {rotary valves}
- F16K: VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING {(devices for emptying and evacuating the excess liquid in valves or conduits F16L55/07)}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A fluid transfer valve has ports arranged in groups. The valve has a rotor having channels and an actuator is operably connectable to the rotor. The actuator is positionable in a loading orientation in which the first channel is connected to one or two of the ports to transfer fluid into the first channel and/or the second channel is connected to one or two of the ports to transfer a second fluid into the second channel. The actuator also is positionable into first and second injection orientations in which various ones of the channels and ports are connected for different fluid flow configurations. Each channel has two ends located on a virtual circle whose center coincides with the rotor's axis of rotation. The channels can have a semicircular shape, a semi-oval shape or a U-shape. An analytical system and method that use the inventive valve are also disclosed.

## Claims

### Claim 1

A valve for transferring at least one fluid, comprising:
a stator comprising a plurality of ports arranged in groups, a first of the groups having at least two first ports, a second of the groups having at least two second ports, and a third of the groups having at least two third ports;
a rotor having a first channel having two ends and a second channel having two ends; and
an actuator operably connectable to the rotor and configured to rotate the rotor into a loading orientation in which one or both of the following situations are present:
a) the first channel is connected to the first ports with one of the first ports being fluidically connected at one of the two ends of the first channel and another of the first ports being fluidically connected at the other of the two ends of the first channel, whereby a first fluid is transferable via at least one of the first ports into the first channel;
b) the second channel is connected to the second ports with one of the second ports being fluidically connected at one of the two ends of the second channel and another of the second ports being fluidically connected at the other of the two ends of the second channel, whereby a second fluid is transferable via at least one of the second ports into the second channel;
wherein the actuator is further configured to rotate the rotor into a first injection orientation and a second injection orientation, wherein in the first injection orientation the first channel is connected to the third ports and the first fluid is transferable from the first channel into at least one of the third ports, wherein in the second injection orientation the second channel is connected to the third ports and the second fluid is transferable from the second channel into at least one of the third ports;
wherein the channels are elongate channels which are only partially located on a virtual circle, a center point of which corresponds to an axis of rotation of the rotor, wherein the two ends of each channel are located on the virtual circle with each channel being configured to transfer the at least one fluid from one of the two ends to the other of the two ends and each of the channels define a shape between the two ends of the channel wherein the shape is selected from the group consisting of a semicircular shape, a semi-oval shape and a U-shape.

### Claim 2 (depends on 1)

The valve according to claim 1, wherein the first and second channels are each configured such that when the first and second channels are connected to a respective one of the groups of ports, the first and second channels form first and second loops, respectively, wherein fluid is transferable between at least one of the ports of the respective group of ports and the respective channel.

### Claim 3 (depends on 1)

The valve according to claim 1, wherein the plurality of ports further comprises a fourth group having at least two fourth ports and wherein the channels further comprise an additional channel, wherein in the loading orientation, the following situation is present:
the additional channel is connected to the fourth ports such that a fourth fluid is transferable into the additional channel; and
the actuator is further configured to rotate the rotor into at least one third injection orientation, wherein in the third injection orientation the fourth fluid is transferable from the additional channel into at least one of the third ports.

### Claim 4 (depends on 1)

The valve according to claim 1, wherein at least one of the channels has a volume of 1 nl to 500 nl.

### Claim 5 (depends on 1)

The valve according to claim 1, wherein one or more of the channels have a length of 0.5 mm to 5 mm.

### Claim 6 (depends on 1)

The valve according to claim 1, wherein the first and second channels comprise first channel and second channel ends, respectively, wherein the first channel end and the second channel end face each other and a distance d between the first channel end and the second channel end is at least 1 mm.

### Claim 7 (depends on 1)

The valve according to claim 1, wherein the rotor has a thickness of at least 1.5 mm.

### Claim 8 (depends on 1)

The valve according to claim 1, wherein the first and second channels have first and second distances d1 and d2, respectively, to an axis of rotation of the rotor, wherein d1 and d2 are essentially equal.

### Claim 9 (depends on 1)

An analytical system for analyzing a sample, comprising:
a valve according to claim 1; and
an analytical device fluidly connectable to the two third ports.

### Claim 10 (depends on 9)

The analytical system according to claim 9, further comprising:
a sample separator fluidly connectable to the first ports;
a characterization unit located between the sample separator and the first ports, the characterization unit being configured for characterization of at least one property of the first fluid.

### Claim 11 (depends on 1)

A method for transferring at least one fluid, comprising:
providing a valve according to claim 1;
with the rotor in the loading orientation, conducting one or both of (i) feeding the first fluid into the first channel while the first channel is connected to the first ports and (ii) feeding the second fluid into the second channel while the second channel is connected to the second ports;
rotating the rotor into the first injection position to thereby transfer the first fluid to one of the third ports; and
rotating the rotor into the second injection position to thereby transfer the second fluid to one of the third ports.

### Claim 12 (depends on 11)

The method according to claim 11, wherein the ports further comprise at least two fourth ports and the channels further comprise an additional channel, wherein the method further comprises the following steps:
feeding a fourth fluid into the additional channel with the rotor in the loading orientation and the additional channel connected to the fourth ports;
transferring the fourth fluid to one of the third ports by rotating the rotor into a third injection orientation from the second injection orientation.

### Claim 13 (depends on 1)

A method of using the valve of claim 1, for a purpose selected from the group consisting of: mass spectroscopy detection of protein analysis and proteomics like protein charge variants or of proteoforms and of metabolite analysis and metabolomics; connection of electro driven separation techniques and chromatographic separation to a mass spectrometer.

### Claim 14 (depends on 1)

The valve according to claim 1, wherein the rotor defines a plurality of linear cavities configured to receive excessive fluid, wherein the plurality of cavities are arranged in an alternating manner with the first channel and the second channel; and
wherein each of the plurality of linear cavities has an outer end located on an outer virtual square and an inner end located on an inner virtual square wherein the outer virtual square and the inner virtual square both have a common center point that coincides with the center point of the virtual circle with the inner virtual square and the outer virtual square having different rotational orientations relative to the common center point.