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US 12,110,540 B2Granted
Compositions and methods for detecting toxigenic Clostridium difficile
AssigneeGen-Probe Incorporated
InventorPatrick Lynn Peterson
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Abstract
Provided herein are compositions, kits, and methods for detecting at least one of a C. diffcile tcdA, tcdB, tcdC, cdtA, or cdtB nucleic acid in a sample. In son embodiments, one or more alleles of tcdC such as 117del tcdC or 184T tcdC are detected.
Claims12
A composition or kit comprising:
- a detection oligomer comprising the sequence set forth in positions 7-18 of SEQ ID NO:
- 305, wherein the detection oligomer further comprises sufficient additional sequence to specifically hybridize to a C. difficile tcdB nucleic acid, and wherein the detection oligomer is non-extendable;
- and
- at least one secondary detection oligomer, comprising a secondary detection oligomer that is configured to interact with a fragment of the detection oligomer, comprises at least two labels, and comprises the sequence of SEQ ID NO:
- 12.
2 more elements
Dependencies are inferred from the claim text.