# US 12,110,501 B2 · Neurogenesis stimulant, internal agent, culture medium additive, cell diluent additive, culture medium, and cell diluent

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- Number: US 12,110,501 B2
- Document ID: US12110501B2
- Status: Granted
- Kind: B2
- Application number: 17/057,402
- Filed: 2018-11-30
- Published: 2021-07-08
- Granted: 2024-10-08
- Earliest claimed: 2018-05-23
- Assignees: Laimu Corporation
- Applicants: Laimu Corporation
- Inventors: Akihiro Tai; Takeru Koga; Sachio Wakayama
- Web page: https://patentgrep.com/patent/US12110501B2

## CPC

- C12N 5/0618: {Cells of the nervous system}
- A61K 31/57: substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K 31/575: substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- C12N 2501/39: Steroid hormones
- C12N 2506/45: from artificially induced pluripotent stem cells
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A neurogenesis stimulant containing a compound having a structure represented by the following formula. R1 to R3 each are an alkyl group having 1 to 10 carbon atoms, and the broken line means presence or absence of a bond.

## Claims

### Claim 1

A method for promoting neural differentiation induced by a nerve growth factor, comprising adding the nerve growth factor and a compound having a structure represented by the following formula (1) to a culture medium for stem cells:
wherein R1 to R3 each independently represent an alkyl group having 1 to 10 carbon atoms, and the broken line means presence or absence of a bond.