# US 12,110,486 B2 · Bifidobacterium bacteria and composition including novel Bifidobacterium bacteria

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- Number: US 12,110,486 B2
- Document ID: US12110486B2
- Status: Granted
- Kind: B2
- Application number: 18/146,706
- Filed: 2022-12-27
- Published: 2023-05-04
- Granted: 2024-10-08
- Earliest claimed: 2017-12-08
- Assignees: Morinaga Milk Industry Co., Ltd.
- Applicants: Morinaga Milk Industry Co., Ltd.
- Inventors: Toshitaka Odamaki; Kumiko Kato
- Web page: https://patentgrep.com/patent/US12110486B2

## CPC

- C12N 1/20: Bacteria; Culture media therefor
- C12N 1/205: Bacterial isolates
- A23L 2/52: Adding ingredients (adding preservatives A23B70/10)
- A23L 33/125: containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates (indigestible substances A23L33/21)
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 35/745: Bifidobacteria
- A61K 47/26: Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/02: Immunomodulators
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23V 2400/533: Longum
- A61K 2035/11: {Medicinal preparations comprising living procariotic cells}
- A61K 2035/115: {Probiotics}
- C12R 2001/01: Bacteria or Actinomycetales {; using bacteria or Actinomycetales}
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

Provide are beneficial bacteria that can be beneficially applied across a wide range of age groups and a composition containing the same. Bifidobacterium longum subspecies longum NITE BP-02568 and/or Bifidobacterium longum subspecies longum NITE BP-02569; and Bifidobacterium longum subspecies longum, having utilization ability for 2′-fucosyllactose are also provided. More preferably, bacteria having utilization ability for carbohydrates arabinoxylan, arabinan, and pectic galactan; and a composition containing the bacteria are also provided. More preferably, a composition containing 2′-fucosyllactose are also provided. More preferably, a composition containing at least one carbohydrate selected from the group consisting of arabinoxylan, arabinan, pectic galactan, and oligosaccharides derived therefrom or containing at least a carbohydrate derived from a gramineous plant or a carbohydrate derived from a solanaceous plant are also provided.

## Claims

### Claim 1

A granular bacterial powder of Bifidobacterium longum subspecies longum NITE BP-02569.

### Claim 2 (depends on 1)

The granular bacterial powder of claim 1, wherein said Bifidobacterium is able to utilize 2′-fucosyllactose, and wherein said Bifidobacterium is further able to utilize a carbohydrate selected from the group consisting of arabinoxylan, arabinan, pectic galactan, and combinations thereof.

### Claim 3

A method for producing a granular bacterial powder containing microorganisms that are classified as Bifidobacterium longum subspecies longum and are able to utilize 2′-fucosyllactose, and wherein said bacterium is further able to utilize a carbohydrate selected from the group consisting of arabinoxylan, arabinan, pectic galactan, and combinations thereof; wherein said method comprises:
i) culturing Bifidobacterium longum subspecies longum NITE BP-02569;
ii) concentrating and lyophilizing the result of said culturing to produce a granular bacterial powder.