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US 12,110,336 B2Granted
Method for treating a neurodegenerative disease by administering an anti-cellular prion protein (PrPc) antibody
AssigneeMedImmune, LLC
InventorsMatthew Gardener, Jayne Hammersley, Maria Groves, Gareth Rees, Sadhana Podichetty, Andrew Billinton
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Abstract
The present disclosure provides antibodies and antigen-binding fragments capable of binding PrPC. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.
Claims2
A method for treating a neurodegenerative disorder in a subject in which aberrant PrPc activity is involved, comprising:
- administering to the subject a pharmaceutically effective amount of an antibody or an antigen-binding fragment comprising a light chain variable (VL) domain and a heavy chain variable (VH) domain, wherein the VH domain comprises:
- a VH CDR 1 having the amino acid sequence of SEQ ID NO:
- 5;
- a VH CDR2 having the amino acid sequence of SEQ ID NO:
- 6;
- and
- a VH CDR3 having the amino acid sequence of SEQ ID NO:
- 7;
- and
- the VL domain comprises:
- a VL CDR1 having the amino acid sequence of SEQ ID NO:
- 14;
- a VL CDR2 having the amino acid sequence of SEQ ID NO:
- 15;
- and
- a VL CDR3 having the amino acid sequence of SEQ ID NO:
- 16;
- and
- wherein the neurodegenerative disorder is one of:
- Alzheimer's Disease, disease associated with misfolded PrP, Creutzfeldt-Jakob Disease, Gerstmann-Sträussler-Schenker Disease, Fatal Familial Insomnia, bovine spongiform encephalopathy, scrapie, chronic wasting disease, transmissible mink encephalopathy, and feline spongiform encephalopathy.
17 more elements
Dependencies are inferred from the claim text.