Peptide analogs
AssigneeAdepthera LLC
InventorSheau Yu Teddy Hsu
Life of this patent
Estimating the term…
Abstract
Analogs for CLR/RAMP receptor ligands are provided that have agonist, superagonist, antagonist, super-antagonist, or multiple receptor modulating activity. The analogs can be selective for one or more CLR/RAMP receptors, or can be pan-specific for multiple G protein-coupled receptors.
Claims7
A Multiple Receptor Ligand (MRL), comprising
- (Glp)RPRLSHKGP(Nle)PF-miniPEG-K(PAL)GCRFGTCTVQKLAHQIYQFTDKDVAPRSKISPQGY-NH2 (SEQ ID 228) or (Glp)RPRLSHKGP(Nle)PF-miniPEG-K(gamma-Glu-PAL)GCRFGTCTVQKLAHQIYQFTDKDVAPRSKISPQGY-NH2 (SEQ ID 229), or a pharmaceutically acceptable salt thereof,
- wherein miniPEG is —NH(CH2CH2O)2CH2C(═O)— and Pal is palmitoyl.
A Multiple Receptor Ligand (MRL), comprising a human apelin polypeptide covalently linked to -miniPEG-SEQ ID NO:110 or a pharmaceutically acceptable salt thereof, wherein miniPEG is —NH(CH2CH2O)2CH2C(═O)— and Pal is palmitoyl.
A Multiple Receptor Ligand (MRL) comprising an amino acid sequence having greater than 95% sequence identity to the amino acid sequence of SEQ ID NO:
- 228.
Dependencies are inferred from the claim text.