Self-immolative systems
AssigneeThe Secretary of State for Defence
InventorsAndrew Russell, Wayne Cord Hayes, Mark Rodney Sambrook, Flavien Leroux, Aaron Acton, Antonio Feula, Alexander Gabriel Gavriel
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Abstract
The present invention is concerned with self-immolative recognition and/or responsive systems for electrophilic compounds, especially alkylating agents, which systems may comprise disclosure or detection of the alkylating agent. The present invention is especially concerned with non-protic triggered self-immolative systems, molecules, and methods, and in particular for detection of non-protic electrophilic agents, and especially alkylating agents, for example alkyl or benzylic halides, which may be found in pesticides or fumigants, or chemical warfare agents.
Claims12
A self-immolative molecule suitable to be triggered by non-protic electrophilic agents, having structural formula:
- wherein Nu is phosphorus (P), R1 and R2 comprise phenyl functional groups or substituted phenyl functional groups, and releasable portion is a chemical moiety capable of generating a detection/measurable response upon release.
A self-immolative triggered method for interrogating a sample suspected of comprising a non-protic electrophilic agent comprising contacting the sample, in the presence of a mild base, with a self-immolative molecule suitable to be triggered by non-protic electrophilic agents, wherein the self-immolative molecule comprises at least one trigger portion linked to at least one releasable portion via a self-immolative portion, and wherein the self-immolative molecule has a structural formula:
- wherein Nu is phosphorus (P) and R1 and R2 comprise phenyl functional groups or substituted phenyl functional groups.
Dependencies are inferred from the claim text.