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US 12,110,302 B2Granted
Metal complex, intermediate, and preparation method and application thereof
AssigneeShanghai Institute of Organic Chemistry, Chinese Academy of Sciences
InventorsWenjun Tang, Siyao Xu
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Abstract
Provided is a metal complex as represented by formula I. The metal complex may be used as a catalyst for asymmetric catalytic hydrogenation, is capable of efficiently catalyzing and synthesizing a series of chiral p-aryl amides having high optical purity, and is especially capable of asymmetrically catalyzing and hydrogenating a tetra-substituted enamide compound, chiral amides having high optical purity are synthesized, and the carrying amount of ligand may reach 100,000.
Claims10
A metal complex according to Formula I:
- Wherein, R1 and R2 are each independently hydrogen, C1-C10 alkyl, C1-C4 alkoxy, C3-C30 cycloalkyl, halogen or C6-C30 aryl;
- Mn+ is a transition metal ion;
- n is 1, 2 or 3, which corresponds to the ion valence of the transition metal M;
- the carbons atoms marked with * are all S configuration chiral carbons or all R configuration chiral carbons;
- the P marked with * are all S configuration chiral P or all R configuration chiral P;
- R− is an anion.
3 more elements
A compound II, which has any of the following structures:
Dependencies are inferred from the claim text.