# US 12,110,301 B2 · Anti-cancer composition containing gold and cytotoxic agent

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- Number: US 12,110,301 B2
- Document ID: US12110301B2
- Status: Granted
- Kind: B2
- Application number: 18/606,890
- Filed: 2024-03-15
- Published: 2024-08-22
- Granted: 2024-10-08
- Earliest claimed: 2019-08-28
- Assignees: King Fahd University of Petroleum and Minerals
- Applicants: King Fahd University of Petroleum and Minerals
- Inventors: Anvarhusein A. Isab; Adam Ahmed Abdullah Sulaiman
- Web page: https://patentgrep.com/patent/US12110301B2

## CPC

- C07F 1/005: {without C-Metal linkages}
- A61P 35/00: Antineoplastic agents
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A gold(III) complex of formula (I) or formula (II) wherein R1 and R2 are each independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, or an optionally substituted aryl; R3 and R4 are each independently a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted alkoxy, a hydroxyl, a halo, a nitro, a cyano, a N-monosubstituted amino group, or a N,N-disubstituted amino group; and X is Cl, Br, or I. A pharmaceutical composition containing the gold(III) complex of formula (I) or (II), and a method of treating cancer are included.

## Claims

### Claim 1

An anticancer composition, comprising:
a dithiocarbamate gold (III) complex of formula (I),
and
a second therapeutic agent with cytotoxic activity selected from the group consisting of daunorubicin, doxorubicin, idarubicin, mitomycin, actinomycin, and epirubicin;
wherein:
R1 and R2 are each independently a hydrogen or an ethyl;
R3 and R4 are each independently a hydrogen;
and X is Cl or Br.

### Claim 2 (depends on 1)

The anticancer composition of claim 1, wherein R1 and R2 are each ethyl.

### Claim 3 (depends on 1)

The anticancer composition of claim 1, wherein R3 and R4 are each hydrogen.

### Claim 4 (depends on 1)

The anticancer composition of claim 1, wherein X is Cl.

### Claim 5

An anticancer composition, comprising:
a dithiocarbamate gold (III) complex of formula (II),
and
a second therapeutic agent with cytotoxic activity selected from the group consisting of daunorubicin, doxorubicin, idarubicin, mitomycin, actinomycin, and epirubicin;
wherein:
R1 and R2 are each independently a hydrogen or an ethyl;
R3 and R4 are each independently an optionally substituted alkyl, an optionally substituted cycloalkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted heterocyclyl, an optionally substituted alkoxy, a hydroxyl, a halo, a nitro, a cyano, a N-monosubstituted amino group, or a N,N-disubstituted amino group; and
X is Cl or Br.

### Claim 6 (depends on 5)

The anticancer composition of claim 5, wherein R1 and R2 are each ethyl.

### Claim 7 (depends on 5)

The anticancer composition of claim 5, wherein R3 and R4 are each hydroxyl.

### Claim 8 (depends on 5)

The anticancer composition of claim 5, wherein X is Cl.