# US 12,109,759 B2 · System for producing a graft device with a three dimensional covering

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- Number: US 12,109,759 B2
- Document ID: US12109759B2
- Status: Granted
- Kind: B2
- Application number: 18/120,260
- Filed: 2023-03-10
- Published: 2023-11-09
- Granted: 2024-10-08
- Earliest claimed: 2016-06-10
- Assignees: Xeltis AG
- Applicants: Xeltis AG
- Inventors: Matthew Mannarino; Jon McGrath; Cory Leeson; Mohammed El-Kurdi; Danielle McDowell; Kermit Santiago; J. Christopher Flaherty
- Web page: https://patentgrep.com/patent/US12109759B2

## CPC

- B29C 64/386: Data acquisition or data processing for additive manufacturing
- A61F 2/06: Blood vessels
- A61M 1/3655: {Arterio-venous shunts or fistulae}
- A61M 27/002: {Implant devices for drainage of body fluids from one part of the body to another (intraocular A61F9/00781; middle ear A61F11/202)}
- B29C 64/10: Processes of additive manufacturing
- B33Y 10/00: Processes of additive manufacturing
- B33Y 30/00: Apparatus for additive manufacturing; Details thereof or accessories therefor
- B33Y 50/00: Data acquisition or data processing for additive manufacturing
- B33Y 80/00: Products made by additive manufacturing
- A61F 2240/002: Designing or making customized prostheses
- A61M 2207/00: Methods of manufacture, assembly or production
- A61M 2207/10: Device therefor
- B29L 2031/7534: {Cardiovascular protheses}
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B33Y: ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B29L: INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES

## Abstract

A system for producing a graft device for a patient may comprise: an imaging device configured to produce image data of a tubular conduit; and a processing unit configured to receive the image data from the imaging device. The processing unit may comprise an algorithm configured to process the image data, and produce a construction signal based on the image data. A material delivery device may be configured to receive the construction signal from the processor, and deliver material to produce a 3D covering based on the construction signal. The graft device may comprise the 3D covering positioned about the tubular conduit. Graft devices and methods of producing graft devices may also be provided.

## Claims

### Claim 1

A method for producing a graft device, comprising:
(a) imaging an electrospun conduit;
(b) producing image data of the imaged electrospun conduit;
(c) generating a construction signal based on the produced image data; and
(d) delivering a material to produce a covering about the electrospun conduit based on the generated construction signal, wherein the graft device comprises the covering positioned about the electrospun conduit, wherein at least one physical property of the covering is defined by thickness data of the electrospun conduit.

### Claim 2 (depends on 1)

The method as set forth in claim 1, wherein the graft device comprises an implant selected from the group consisting of artery bypass graft, coronary artery bypass graft, dialysis graft, peripheral arterial bypass graft, great vessel replacement, great vessel bypass graft, esophageal graft, tracheal graft, bronchial graft, biliary duct graft, intestinal graft, organ transplant vascular connection graft, neuronal replacement implant, ligament graft, ligament replacement, tendon graft, tendon replacement, transplant organ coating, fallopian tube, urethra, ureter, cartilage, hip joint, shoulder joint, intervertebral disc, menisci, and any combination thereof.

### Claim 3 (depends on 1)

The method as set forth in claim 1, wherein the material comprises one or more materials selected from the group consisting of: synthetic polymer, natural polymer, protein, metal, metal alloy, collagen, elastin, a glycosaminoglycan, a proteoglycan, an alginate, cellulose, gelatin, silk fibroin, fibrinogen, chitosan, an enzyme, fibronectin, glycerin, integrin, keratin, a vitamin, a carbohydrate, a monosaccharide, a disaccharide, a polysaccharide, a nucleoside, abductin, lignin, a glycolipid, a phospholipid, a sterol, shrilk, cobalt-chrome, nitinol, aluminum oxide, magnesium, iron, zinc, steel, titanium, vitalium, alacrite, platinum, gold, silver, copper, manganese, a polyester, a polyurethane, a polycarbonate, a polyether, a polysulfone, a polyamide, a polyetheramide, a polystyrene, a polybutadiene, a polyisoprene, a poly(methyl methacrylate), a polyanhydride, a polydimethylsiloxane, a polydioxanone, polyethylene, glycol, polyethylene terephthalate, a polyglycolide, a polyhydroxyalkanoate, polyimide, polytetrafluoroethylene, polyvinylidene fluoride, polyethylene, polypropylene, polyvinylfluoride, polyvinylchloride, polyacylonitrile, silicone, a ceramic, a bioceramic, a bioglass, a composite material, and any combination thereof.