# US 12,109,567 B2 · Robotic liquid handling system

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- Number: US 12,109,567 B2
- Document ID: US12109567B2
- Status: Granted
- Kind: B2
- Application number: 17/511,021
- Filed: 2021-10-26
- Published: 2022-04-28
- Granted: 2024-10-08
- Earliest claimed: 2020-10-28
- Assignees: Tecan Trading AG
- Applicants: Tecan Trading AG
- Inventors: Christian Berweger; Ermal Abdulahi; Mirco Brennwald
- Web page: https://patentgrep.com/patent/US12109567B2

## CPC

- B01L 3/523: {with means for closing or opening}
- G01N 35/0099: {comprising robots or similar manipulators (robots per se B25J)}
- G01N 35/04: Details of the conveyor system {(G01N35/021 - G01N35/028 take precedence)}
- B01L 2200/16: Reagents, handling or storing thereof
- B01L 2300/044: pierceable, e.g. films, membranes
- G01N 2035/0405: {manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers}
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A robotic liquid handling system may be provided comprising a robotic arm and a controller configured to control the robotic arm to position and operate the robotic arm in a workspace of the robotic liquid handling system. The controller may be configured to, as part of a liquid handling task, control the robotic arm to open a reagent reservoir, wherein the reagent reservoir has an opening which is sealed by a foil. The controller may be configured to control the robotic arm to open the foil by controlling the robotic arm to, using a cutting tip (260), cut at least two flaps in the foil, and using a blunt protrusion, push the at least two flaps downwards into the reagent reservoir to clear at least part of the opening of the reagent reservoir. Further aspects of the invention relate to a computer-implemented method for controlling a robotic arm and to an opening tool (200) comprising the cutting tip and the blunt protrusion.

## Claims

### Claim 1

A robotic liquid handling system, comprising:
at least one robotic arm;
a controller configured to control the robotic arm to position and operate the robotic arm in a workspace of the robotic liquid handling system; wherein
the controller is configured to, as part of a liquid handling task, control the robotic arm to open a reagent reservoir, wherein the reagent reservoir has an opening which is sealed by a foil, wherein the controller is configured to control the robotic arm to open the foil by controlling the robotic arm to:
(i) using a cutting tip, cut at least two flaps in the foil; and
(ii) using a blunt protrusion, push the at least two flaps downwards into the reagent reservoir to clear at least part of the opening of the reagent reservoir, wherein
the controller is configured to cut the at least two flaps in the foil by controlling the robotic arm to:
with the cutting tip, pierce the foil at an entry position; and
from the entry position, move the cutting tip laterally with the cutting tip inserted into the opening at a first depth past a height of the foil.

### Claim 2 (depends on 1)

The robotic liquid handling system according to claim 1, wherein the controller is configured to control the robotic arm to cut a H-shaped or X-shaped pattern in the foil to establish the at least two flaps.

### Claim 3 (depends on 2)

The robotic liquid handling system according to claim 2, wherein the controller is configured to control the robotic arm to cut the H-shaped or X-shaped pattern in the foil by controlling the robotic arm to:
cut a central slit across the foil, and cut from the central slit in both directions perpendicularly or diagonally away from the central slit towards a periphery of the opening to establish at least one flap at each side of the central slit.

### Claim 4 (depends on 3)

The robotic liquid handling system according to claim 3, wherein the opening is a rectangular opening having a width and a length, and wherein the controller is configured to control the robotic arm to:
cut the central slit centrally along the length of the opening; and
cut from each respective end of the slit in both directions towards a corner of the opening.

### Claim 5 (depends on 4)

The robotic liquid handling system according to claim 4, wherein the blunt protrusion has as a width which spans at least 75% of the width of the opening, and wherein the controller is configured to control the robotic arm to push the two flaps downwards with the blunt protrusion oriented so that the width of the blunt protrusion is parallelly aligned with the width of the opening.

### Claim 6 (depends on 3)

The robotic liquid handling system according to claim 3, wherein the controller is configured to, as part of clearing the opening of the reagent reservoir, control the robotic arm to individually push the blunt protrusion downwards at a number of positions along the central slit.

### Claim 7 (depends on 6)

The robotic liquid handling system according to claim 6, wherein the controller is configured to, after individually pushing the blunt protrusion downwards at the number of positions along the central slit, control the robotic arm to:
insert the blunt protrusion into the opening past a height of the foil; and
move the blunt protrusion along the length of the central slit.

### Claim 8 (depends on 1)

The robotic liquid handling system according to claim 1, wherein the controller is configured to control the robotic arm to, after moving the cutting tip laterally along a cutting path at the first depth, move the cutting tip laterally along at least part of the cutting path with the cutting tip inserted into the opening at a second depth past the height of the foil, wherein the second depth exceeds the first depth.

### Claim 9 (depends on 1)

The robotic liquid handling system according to claim 1, wherein the reagent reservoir is a rectangularly-shaped reagent trough.

### Claim 10 (depends on 1)

The robotic liquid handling system according to claim 1, wherein the controller is configured to control the robotic arm to:
pick-up an opening tool, wherein the opening tool comprises the cutting tip and the blunt protrusion;
use the cutting tip of the opening tool to create the at least two flaps in the foil; and
use the blunt protrusion of the opening tool to clear at least part of the opening of the reagent reservoir.

### Claim 11 (depends on 10)

The robotic liquid handling system according to claim 10, wherein
the opening tool has two opposing surfaces by which the opening tool can be gripped and picked-up, wherein
the robotic arm is arranged to mount a pair of grippers to pick-and-place objects in a workspace of the robotic liquid handling system, and wherein
the controller is configured to control the robotic arm to pick-up the opening tool by gripping the opening tool with the pair of grippers at the two opposing surfaces.

### Claim 12 (depends on 10)

A kit-of-parts comprising the robotic liquid handling system and the opening tool according to claim 10.

### Claim 13 (depends on 12)

The kit-of-parts according to claim 12, wherein the opening tool comprises:
a main body with an elongated shape, the elongated shape having at each respective end of the elongated shape a surface to provide two opposing surfaces at which the opening tool can be laterally gripped and picked-up;
an elongated surface which runs along a length of the main body, wherein the elongated surface comprises:
(i) at one end of the elongated surface, the cutting tip for piercing and cutting the foil of the reagent reservoir; and
(ii) at an opposing end of the elongated surface, the blunt protrusion for pushing flaps cut into the foil downwards into the opening of the reagent reservoir, wherein the blunt protrusion is blunt in relation to the cutting tip.

### Claim 14 (depends on 13)

The kit-of-parts according to claim 13, wherein the elongated main body comprises at each respective end of the elongated shape a respective recess, wherein each respective recess provides the opposing surfaces to be gripped.

### Claim 15 (depends on 13)

The kit-of-parts according to claim 13, wherein the cutting tip has pyramidal shape having an apex projecting away from the elongated surface.

### Claim 16 (depends on 13)

The kit-of-parts according to claim 13, wherein the cutting tip is made of a glass fiber reinforced thermoplastic.

### Claim 17 (depends on 16)

The kit-of-parts according to claim 16, wherein the cutting tip is made from a glass fiber reinforced polyetheretherketone (PEEK).

### Claim 18 (depends on 1)

A computer-implemented method for controlling the robotic liquid handling system according to claim 1, wherein the method comprises controlling the robotic arm to open a foil sealing an opening of a reagent reservoir by the steps of:
(a) using a cutting tip, cut at least two flaps in the foil by piercing the foil with the cutting tip at an entry position and from the entry position moving the cutting tip laterally with the cutting tip inserted into the opening at a first depth past a height of the foil; and
(b) using a blunt protrusion, push the at least two flaps downwards into the reagent reservoir to clear at least part of the opening of the reagent reservoir.

### Claim 19 (depends on 18)

The computer-readable medium comprising transitory or non-transitory data representing a computer program, the computer program comprising instructions for causing a processor system to perform the method according to claim 18.