Methods of solvent removal at ambient temperatures—cryovap

A method of removing at least one solvent from a mixture comprising the at least one solvent and a product, the method comprising:

• a) providing an apparatus comprising a first container, a second container, and a hollow tube, wherein:
• i) the first and second containers are fluidically connected to each other via the hollow tube;
• ii) the first container, second container or hollow tube further comprise a stopcock;
• iii) the first container contains the mixture comprising the at least one solvent and the product, wherein the at least one solvent is high-boiling solvent, and the mixture is maintained at an ambient temperature;
• and
• iv) the second container contains the at least one solvent alone;
• b) adding a volatile co-solvent to the first container and the second container;
• c) opening the stopcock and applying a vacuum via a vacuum pump to the apparatus, via the stopcock, for a time, then closing the stopcock, wherein a vapor pressure of the volatile co-solvent is higher than a pressure provided by the vacuum pump;
• d) optionally warming the first container to a first temperature, for a first period;
• e) cooling the second container to a second temperature, for a second period;
• and
• f) recovering the product from the first container and the at least one solvent from the second container,
• wherein the volatile co-solvent is selected from the group consisting of:
• hydrocarbons;
• chlorinated hydrocarbons;
• polar aprotic solvents;
• water;
• and alcohols.