# US 12,109,442 B2 · Oral care compositions and methods of use

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- Number: US 12,109,442 B2
- Document ID: US12109442B2
- Status: Granted
- Kind: B2
- Application number: 15/539,230
- Filed: 2014-12-26
- Published: 2017-12-07
- Granted: 2024-10-08
- Earliest claimed: 2014-12-26
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Wilbens Josias; Richard Robinson; Adam Pepperney; Kimdra Smith-Webster
- Web page: https://patentgrep.com/patent/US12109442B2

## CPC

- A61K 8/34: Alcohols
- A61K 8/19: containing inorganic ingredients
- A61K 8/24: Phosphorous; Compounds thereof
- A61K 8/27: Zinc; Compounds thereof
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/466: {containing sulfonic acid derivatives; Salts}
- A61K 8/49: containing heterocyclic compounds
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

This invention relates to oral care compositions comprising a basic amino acid or salt thereof, a zinc source, and a preservative, as well as to methods of using and of making these compositions.

## Claims

### Claim 1

An oral care composition comprising:
arginine, in free or salt form;
a mixture comprising zinc oxide and zinc citrate;
a preservative, wherein the preservative is benzyl alcohol, wherein the benzyl alcohol is in an amount of 0.7% by wt., wherein the arginine is present in an amount of 1% to 15% wt. based on the weight of the oral care composition, the weight of the arginine being calculated as free base form, wherein zinc oxide is present in an amount of 1% wt. based on the weight of the oral care composition, and wherein the zinc citrate is in an amount of from 0.5% wt. based on the weight of the oral care composition; and
wherein the pH of the oral care composition is between 7.5 and 10.5.

### Claim 2 (depends on 1)

The oral care composition of claim 1, wherein the arginine is L-arginine.

### Claim 3 (depends on 1)

The oral care composition of claim 1, wherein the arginine is present at about 8% wt.

### Claim 4 (depends on 1)

The oral care composition of claim 1, wherein the ratio of zinc oxide to zinc citrate is 2:1.

### Claim 5 (depends on 1)

The oral care composition of claim 1, wherein the composition further comprises tetrasodium pyrophosphate, and wherein the tetrasodium pyrophosphate is in an amount of 0.2%-1.0% wt. based on the weight of the oral care composition.

### Claim 6 (depends on 1)

The oral care composition of claim 1, wherein the composition further comprises tetrasodium pyrophosphate, and wherein the tetrasodium pyrophosphate is in an amount of about 0.5% wt. based on the weight of the oral care composition.