# US 12,109,439 B2 · Method of estimating dosimetric characteristics X-ray convergent irradiator to object to be irradiated > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,109,439 B2 - Document ID: US12109439B2 - Status: Granted - Kind: B2 - Application number: 17/166,064 - Filed: 2021-02-03 - Published: 2021-06-17 - Granted: 2024-10-08 - Earliest claimed: 2013-12-10 - Assignees: Convergent R.N.R Ltd - Applicants: Convergent R.N.R Ltd. - Inventors: Aharon Bar-David; Michael Kleckner; Shirly Borukhin; Zeev Harel - Web page: https://patentgrep.com/patent/US12109439B2 ## CPC - A61N 5/1075: {for testing, calibrating, or quality assurance of the radiation treatment apparatus} - A61N 5/1065: {Beam adjustment} - A61N 2005/1076: {using a dummy object placed in the radiation field, e.g. phantom} - A61N 2005/1085: {characterised by the type of particles applied to the patient} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A method of a radiotherapy or radiosurgery treatment comprises steps of: (a) providing a converging x-ray beam source configured for emitting a converging X-ray beam propagating along an axis thereof; (b) emitting the converging x-ray beam towards a volume of treatment (VOT) having a length along the axis of the converging X-ray beam ranging between 2 mm and 5 cm within a patient's body such that a waist portion is within the VOT; (c) propagating the beam through tissues previously located relative to the VOT (PO); the VOT per se and tissues distally located to the VOT (DO). The converging X-ray beam characterized by a convergent angle ranging between 2 and 30 degrees providing 80% to 100% of a maximum dose is received by the VOT and less than 60% of the maximum dose is received by the PO and the DO. ## Claims ### Claim 1 A method of irradiating a target by an X-ray convergent irradiator with an estimated dose; said method comprising steps of: a.estimating dosimetric characteristics provided by said X-ray convergent irradiator further comprising: i. providing said X-ray convergent irradiator; said irradiator comprising an X-ray source and a lens arrangement configured for forming an X-ray beam with a convergent envelope; said X-ray beam having an optical axis thereof; ii. positioning said X-ray irradiator above a water phantom such that a maximal dose location is located at a predetermined depth; iii. measuring local doses in a plurality of points within said water phantom; iv. obtaining a 3D isodose map of within said convergent envelope propagating in said water phantom; v. determining a maximal dose within said convergent envelope; vi. on a basis of said 3D isodose map, determining a cross-sectional diameter Dw of a focal spot formed by said convergent envelope in a plane transversally oriented to said optical axis; vii. on a basis of said 3D isodose map, determining a cross-sectional diameter De at zero depth in a plane transversally oriented to said optical axis; viii. calculating a percentage ratio of a maximal dose at zero depth to a maximal dose within said focal spot R em = Dose ⁢ at ⁢ zero ⁢ depth Maximum ⁢ dose ⁢ at ⁢ the ⁢ focus ⁢ spot ; ix. calculating a convergence angle given as arctan ⁢ α = arctan ⁡ ( D e - D w 2 ⁢ L ) where De and Dw are cross-sectional diameters of said convergent envelope at said zero depth and said focal spot and L is a distance between said zero depth and focal spot; and x. determining a longitudinal size of said focal spot; b. on a basis of said obtained percentage ratio, convergence angle and longitudinal size of focal spot, estimating the dose to be provided to said target; and c.irradiating said target with said estimated dose. ### Claim 2 (depends on 1) The method according to claim 1, wherein said predetermined depth is 8 cm. ### Claim 3 (depends on 1) The method according to claim 1, wherein said predetermined criterion is a region where 80%-100% of said maximal dose is received. ### Claim 4 (depends on 1) The method of claim 1 wherein said water phantom is an equivalent of a human tissue. ### Claim 5 A method of radio treatment a patient by an X-ray convergent irradiator using a treatment plan with prescribed dose; utilizing data measured by said method comprising steps of a. estimating dosimetric characteristics provided by said X-ray convergent irradiator further comprising: i. providing said X-ray convergent irradiator; said irradiator comprising an X-ray source and a lens arrangement configured for forming an X-ray beam with a convergent envelope; said X-ray beam having an optical axis thereof; ii. positioning said X-ray irradiator above a water phantom such that a maximal dose location is located at a predetermined depth; iii. measuring local doses in a plurality of points within said water phantom; iv. obtaining a 3D isodose map of within said convergent envelope propagating in said water phantom; v. determining a maximal dose within said convergent envelope; vi. on a basis of said 3D isodose map, determining a cross-sectional diameter Dw of a focal spot formed by said convergent envelope in a plane transversally oriented to said optical axis; vii. on a basis of said 3D isodose map, determining a cross-sectional diameter De at zero depth in a plane transversally oriented to said optical axis; viii. calculating a percentage ratio of a maximal dose at zero depth to a maximal dose within said focal spot Rem=Dose at zero depth/maximum dose at the focus spot; ix. calculating a convergence angle given as arctan α=((De-Dy)/2L) where De and Dw are cross-sectional diameters of said convergent envelope at said zero depth and said focal spot and L is a distance between said zero depth and focal spot; and x. determining a longitudinal size of said focal spot; b. on a basis of the obtained percentage ratio, convergence angle and longitudinal size of focal spot, estimating the dose to be provided to said patient; and c. irradiating said target with said estimated dose. ### Claim 6 (depends on 5) The method according to claim 5, wherein said predetermined depth is 8 cm. ### Claim 7 (depends on 5) The method according to claim 5, wherein said predetermined criterion is a region where 80%-100% of said maximal dose is received. ### Claim 8 (depends on 5) The methods of claims 5, wherein said water phantom is an equivalent of a human tissue.