# US 12,109,433 B2 · Efficient treatment of cranio spinal cancers > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,109,433 B2 - Document ID: US12109433B2 - Status: Granted - Kind: B2 - Application number: 18/046,035 - Filed: 2022-10-12 - Published: 2024-04-18 - Granted: 2024-10-08 - Earliest claimed: 2022-10-12 - Assignees: Elekta Limited - Applicants: Elekta, Inc. - Inventors: Louis Arunus Genet; Stuart Julian Swerdloff - Web page: https://patentgrep.com/patent/US12109433B2 ## CPC - A61N 5/10: X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy (A61N5/01 takes precedence) - A61N 5/1043: {Scanning the radiation beam, e.g. spot scanning or raster scanning} - A61N 5/1039: {using functional images, e.g. PET or MRI} - A61N 5/1078: {Fixed beam systems} - A61N 5/1081: {Rotating beam systems with a specific mechanical construction, e.g. gantries} - A61N 2005/1087: {Ions; Protons} - A61N 2005/1095: {Elements inserted into the radiation path within the system, e.g. filters or wedges} - A61N 2005/1096: {Elements inserted into the radiation path placed on the patient, e.g. bags, bolus, compensators} - A61N 2005/1097: {Means for immobilizing the patient} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Systems and techniques may be used for radiotherapy. An example system may include a fixation device arranged to receive and immobilize a patient. The example system may include a first filter arranged to extend along a first portion (e.g., a spine or cranium) of the patient, the first filter attached to the fixation device at a first location, the first filter including a plurality of beam attenuating elements. The example system may include a fixed beam proton delivery system arranged to deliver a therapeutic proton radiation dose attenuated via the first filter to the first portion of the patient. ## Claims ### Claim 1 A system for radiotherapy comprising: a fixation device arranged to receive and immobilize a patient; a first filter arranged to extend along a first portion of the patient, the first filter attached to the fixation device via one or more supports, the first filter including a plurality of beam attenuating elements; a particle treatment system, including an ion source and a plurality of magnets, the particle treatment system arranged to deliver a therapeutic particle radiation dose attenuated via the first filter to the first portion of the patient, wherein the first filter is attached to the fixation device at a first location; and a second filter arranged along a posterior oblique of the patient, the second filter attached to the fixation device at a second location, wherein the particle treatment system is further arranged to deliver a therapeutic proton radiation dose attenuated via the second filter to a second portion of the patient, and wherein the therapeutic proton radiation dose attenuated via the second filter is delivered to the second portion of the patient from a vertical beamline, and the therapeutic proton radiation dose attenuated via the first filter is delivered to the first portion along a different beamline than the vertical beamline. ### Claim 2 (depends on 1) The system of claim 1, wherein the particle treatment system comprises one or more fixed beams or a gantry. ### Claim 3 (depends on 1) The system of claim 1, wherein the first filter is a static ridge filter. ### Claim 4 (depends on 1) The system of claim 1, wherein the vertical beamline is delivered along a spine of the patient and wherein the different beamline is delivered along a cranium of the patient. ### Claim 5 (depends on 1) The system of claim 1, wherein the particle treatment system arranged to deliver the therapeutic particle radiation dose is to deliver a first therapeutic proton radiation dose to a left posterior oblique and to deliver a second therapeutic proton radiation dose to a right posterior oblique of a cranium of the patient, wherein each of the first and second dose point to a same treatment isocenter in the patient. ### Claim 6 (depends on 1) The system of claim 1, wherein the fixation device includes a thermoplastic cast. ### Claim 7 (depends on 1) The system of claim 1, wherein the particle treatment system is arranged to deliver the therapeutic particle radiation dose without anesthetizing the patient. ### Claim 8 (depends on 1) The system of claim 1, wherein the particle treatment system is further arranged to use Intensity Modulated Particle Therapy (IMPT) with Pencil Beam Scanning. ### Claim 9 (depends on 8) The system of claim 8, wherein the particle treatment system is further arranged to use a ramp up and a ramp down of intensity at a junction of fields of delivery along a longitudinal axis of the patient substantially parallel to the first filter. ### Claim 10 (depends on 1) The system of claim 1, wherein a volumetric image is acquired using at least one of Helical CT, Spectral Helical CT, or MR-guided Proton Therapy (MRgPT). ### Claim 11 (depends on 1) The system of claim 1, wherein the particle treatment system is further arranged to deliver the therapeutic particle radiation dose based on conformal FLASH using Ion Range Compensation. ### Claim 12 (depends on 1) The system of claim 1, wherein the therapeutic particle radiation dose is delivered in a field as a proton radiation dose and wherein fractions of the field include two repetitions of 18 Gy. ### Claim 13 A method comprising: receiving a volumetric image of a patient in a single scan; arranging a first filter to extend along a first portion of the patient, the first filter attached to a fixation device via one or more supports at a first location; arranging a second filter along a posterior oblique of the patient, the second filter attached to the fixation device at a second location; registering an image of the patient captured in situ to the volumetric image, the captured image including the patient, the first filter, and the second filter; identifying a treatment position of the patient from a registration; delivering, from a particle treatment system including an ion source and a plurality of magnets, a field of particle radiation therapy to the first portion of the patient attenuated via the first filter, based on the identified treatment position; and delivering, using the particle treatment system, a therapeutic proton radiation dose attenuated via the second filter to a second portion of the patient from a vertical beamline, and wherein the therapeutic proton radiation dose attenuated via the first filter is delivered to the first portion along a different beamline than the vertical beamline. ### Claim 14 (depends on 13) The method of claim 13, wherein the first filter is a static ridge filter. ### Claim 15 (depends on 13) The method of claim 13, wherein the volumetric image is acquired using at least one of Helical CT, Spectral Helical CT, or MR-guided Proton Therapy (MRgPT). ### Claim 16 (depends on 13) The method of claim 13, wherein the vertical beamline is delivered along a spine of the patient and wherein the different beamline is delivered along a cranium of the patient.