# US 12,109,430 B2 · Animal treatment apparatus, phototherapeutic apparatus, and animal treatment method

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- Number: US 12,109,430 B2
- Document ID: US12109430B2
- Status: Granted
- Kind: B2
- Application number: 17/243,865
- Filed: 2021-04-29
- Published: 2021-09-09
- Granted: 2024-10-08
- Earliest claimed: 2018-10-31
- Assignees: Nichia Corporation
- Applicants: Nichia Corporation
- Inventors: Shinpei Kawarai; Atsushi Tsukamoto; Shota Kubota; Yasuo Fujikawa; Tomohiro Tsurumoto; Makiko Yamagishi
- Web page: https://patentgrep.com/patent/US12109430B2

## CPC

- A61N 5/0616: {Skin treatment other than tanning}
- A61D 1/00: Surgical instruments for veterinary use
- A61N 2005/0626: {Monitoring, verifying, controlling systems and methods}
- A61N 2005/0644: {Handheld applicators}
- A61N 2005/0652: {Arrays of diodes}
- A61N 2005/0661: {ultraviolet}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61D: VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS

## Abstract

A method of treating a non-human animal subject includes irradiating, one or more times, light having a peak wavelength in a range of 315-335 nm to an affected area of the animal subject.

## Claims

### Claim 1

A method of treating a non-human animal subject, comprising:
performing a first step comprising irradiating an affected area of skin of the non-human animal subject with light having a first peak wavelength, which is in a range of 315-335 nm at a first irradiation dose; and
one or more days after the first step, performing a second step comprising irradiating the affected area of the skin with light having a second peak wavelength in the range of 315-335 nm at a second irradiation dose, wherein the second peak wavelength is shorter than the first peak wavelength.

### Claim 2 (depends on 1)

The method according to claim 1, wherein:
the first peak wavelength is in a range of 325-335 nm, and
the second peak wavelength is in a range of 315-325 nm.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the light irradiated in the first and second steps has a relative illuminance at wavelengths less than 315 nm of 30% or less.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the method is used to treat a disease or disorder mediated by MrgprX2 gene.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the method is used to treat a disease or disorder selected from the group consisting of allergic dermatitis, cutaneous lymphoma, vitiligo, a wound, alopecia, an infectious disease, a skin abscess, and pyoderma.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the first step further comprises irradiating the affected area with the light having the first peak wavelength at a third irradiation dose that is higher than the first irradiation dose.

### Claim 7 (depends on 6)

The method according to claim 6, wherein:
the first irradiation dose is 300 mJ/cm2 or less, and
the third irradiation dose is more than 300 mJ/cm2 but less than an irradiation dose that would cause sunburn to the skin.

### Claim 8 (depends on 6)

The method according to claim 6, wherein the first step further comprises repeating the step defined in claim 6, with the third irradiation dose increasing each repetition.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the second step further comprises irradiating the affected area with the light having the second peak wavelength at a fourth irradiation dose that is higher than the second irradiation dose.

### Claim 10 (depends on 8, 9)

The method according to claim 9, wherein the second step further comprises repeating the step defined in claim 8, with the fourth irradiation dose increasing each repetition.

### Claim 11 (depends on 1)

The method according to claim 1, further comprising performing a third step comprising irradiating the affected area with light having a third peak wavelength in a range of 305-315 nm at a fifth irradiation dose.

### Claim 12 (depends on 11)

The method according to claim 11, wherein the third step further comprises irradiating the affected area with the light having the third peak wavelength at a sixth irradiation dose that is higher than the fifth irradiation dose.

### Claim 13 (depends on 11, 12)

The method according to claim 12, wherein the third step further comprises repeating the step defined in claim 11, with the sixth dose increasing each repetition.

### Claim 14 (depends on 11)

The method according to claim 11, wherein the fifth irradiation dose is 300 mJ/cm2 or less.

### Claim 15 (depends on 1)

The method according to claim 1, wherein the light having a peak wavelength in the range of 315-335 nm is emitted by a light emitting diode (LED) or laser diode (LD).