US 12,109,411 B2Granted

Systems and methods for detecting fault conditions in electroporation therapy

AssigneeGrand Decade Developments Limited

InventorsJohn Rodriguez, Jason Jin, Brandon Dang Phung, Wesley Joel Ericson, Jodie Marie Houdek, Jonathan Joseph McIntosh, Carlos E. Gonzalez, Anthony Steven Nault

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Abstract

Example systems, apparatuses, methods, and computer program products are disclosed for electroporating cells in a tissue using a set of voltage pulses generated by capacitor charge circuitry based on a voltage supply. An example method includes continuously monitoring a set of characteristics of the voltage supply and the set of voltage pulses; generating a first set of monitor signals based on the set of characteristics; detecting a first fault condition based on the first set of monitor signals; and generating a first crowbar trigger activation signal. The example computer method further includes: detecting a second fault condition based on a second set of monitor signals generated based on the first set of monitor signals; and generating a second crowbar trigger activation signal. Subsequently, the example computer method includes electrically disconnecting the capacitor charge circuitry from electroporation electrode circuitry based on either the first or second crowbar trigger activation signal.

Claims18

Dependent claims

A system for electroporating cells in a tissue using a set of voltage pulses generated based on a voltage supply, the system comprising:

a first monitor circuitry, wherein the first monitor circuitry is in electrical communication with at least one of a voltage generation circuitry that is coupled to a capacitor charge circuitry or an electroporation electrode (EPE) circuitry, and wherein the first monitor circuitry is configured to:
receive a first set of monitor signals,
detect a first fault condition based on the first set of monitor signals,
in response to a detection of the first fault condition, transmit first instructions configured to cause termination of electroporation;
and
a second monitor circuitry, wherein the second monitor circuitry is in electrical communication with at least one of the voltage generation circuitry or the EPE circuitry, and wherein the second monitor circuitry is configured to:
receive a second set of monitor signals,
detect a second fault condition based on the second set of monitor signals,
in response to a detection of the second fault condition, transmit second instructions configured to cause termination of electroporation,
wherein the second set of monitor signals is based on the first set of monitor signals, wherein the first set of monitor signals is a set of analog monitor signals, wherein the second set of monitor signals is a set of digital monitor signals.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/304,605Filed 23 Jun 2021 · continuation
Priority: 6 Feb 2019
Published: US 2021/0353938 A118 Nov 2021
Granted: 8 Oct 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61N 1/325
Alternating or intermittent currents: for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
A61N 1/327
Alternating or intermittent currents: for enhancing the absorption properties of tissue, e.g. by electroporation
A61B 18/1477
Probes or electrodes therefor: needle-like probes
A61N 1/0412
Use-related aspects: specially adapted for transcutaneous electroporation, e.g. including drug reservoirs

Family

Application16/269,022Parent of this continuation · filed 6 Feb 2019
US 2021/0353938 A1Pre-grant publication · published 18 Nov 2021
US 11,071,860 B2Parent of this continuation
US 2020/0246612 A1Published application
US 12,109,411 B2This patent

From the US filing history. Foreign family members aren’t listed.