# US 12,109,405 B2 · Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,109,405 B2 - Document ID: US12109405B2 - Status: Granted - Kind: B2 - Application number: 18/303,991 - Filed: 2023-04-20 - Published: 2023-08-31 - Granted: 2024-10-08 - Earliest claimed: 2018-04-20 - Assignees: The Feinstein Institutes for Medical Research - Applicants: The Feinstein Institutes for Medical Research - Inventors: Jared M. Huston; Jason R. Fritz; Seema G. Amin; Christopher J. Czura; Kevin J. Tracey - Web page: https://patentgrep.com/patent/US12109405B2 ## CPC - A61N 1/0468: {Specially adapted for promoting wound healing} - A61H 23/00: Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms {(apparatus for passive exercising A61H1/00; generating or transmitting mechanical vibrations in general B06B)} - A61H 23/0245: {with ultrasonic transducers, e.g. piezoelectric} - A61H 39/04: Devices for pressing such points, e.g. Shiatsu {or Acupressure}(Massage or pressure on general areas A61H9/00 - A61H23/00) - A61N 1/36034: {specified by the stimulation parameters} - A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092}) - A61H 2201/10: with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy - A61H 2201/1207: with electric or magnetic drive - A61H 2201/1604: Head - A61H 2201/165: Wearable interfaces - A61H 2203/03: especially adapted for animals - A61H 2230/065: used as a control parameter for the apparatus - A61H 2230/305: used as a control parameter for the apparatus (A61H2230/045 takes precedence) - A61N 2007/0017: {Wound healing} - A61N 2007/0026: {Stimulation of nerve tissue} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61H: PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY (electrotherapy, magnetotherapy, radiation therapy or ultrasound therapy A61N) ## Abstract Disclosed are apparatuses and methods for reducing or limiting bleeding (e.g., blood loss and/or bleeding time) in an animal by trigeminal stimulation. The apparatuses and methods may activate one or more branches of the trigeminal nerve. This activation may be invasive or non-invasive. ## Claims ### Claim 1 A method of treating a hemophiliac subject, the method comprising: determining when the subject is bleeding; and applying one or more of mechanical or electrical stimulation to the subject's trigeminal nerve to reduce bleeding wherein applying said one or more of mechanical or electrical stimulation comprises avoiding triggering a diver's reflex, and thereby reducing bleeding. ### Claim 2 (depends on 1) The method of claim 1, further comprising reducing bleeding by at least 10%. ### Claim 3 (depends on 1) The method of claim 1, further comprising reducing bleeding by greater at least 20%. ### Claim 4 (depends on 1) The method of claim 1, wherein applying one or more of mechanical or electrical stimulation comprises stimulating the trigeminal nerve at between 0.1 Hz and 100 Hz for greater than 10 minutes. ### Claim 5 (depends on 1) The method of claim 1, wherein applying said one or more of mechanical or electrical stimulation comprises applying electrical stimulation noninvasively to the subject's trigeminal nerve. ### Claim 6 (depends on 1) The method of claim 1, wherein applying said one or more of mechanical or electrical stimulation comprises applying electrical stimulation between 1-50 Hz and between 0.5-15V having a pulse width of between 0.5 ms and 10 ms. ### Claim 7 (depends on 1) The method of claim 1, wherein applying said one or more of mechanical or electrical stimulation comprises applying non-invasive mechanical stimulation. ### Claim 8 (depends on 1) The method of claim 1, wherein applying said one or more of mechanical or electrical stimulation comprises stimulating one of an ophthalmic, maxillary or mandibular branch of the subject's trigeminal nerve. ### Claim 9 (depends on 1) The method of claim 1, wherein applying said one or more of mechanical or electrical stimulation comprises stimulating two or more of an ophthalmic, maxillary or mandibular branch of the subject's trigeminal nerve. ### Claim 10 (depends on 1) The method of claim 1, wherein applying said one or more of mechanical or electrical stimulation comprises stimulating sensory fibers of the subject's trigeminal nerve. ### Claim 11 (depends on 1) The method of claim 1, wherein applying said one or more of mechanical or electrical stimulation comprises applying unilateral stimulation to the subject's trigeminal nerve. ### Claim 12 (depends on 1) The method of claim 1, wherein applying said one or more of mechanical or electrical stimulation comprises applying bilateral stimulation to the subject's trigeminal nerve. ### Claim 13 (depends on 1) The method of claim 1, wherein reducing said bleeding comprises reducing said bleeding by at least 30%. ### Claim 14 (depends on 1) The method of claim 1, wherein applying said one or more of mechanical or electrical stimulation consists of stimulating the trigeminal nerve.