# US 12,109,372 B2 · Agent delivery devices > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,109,372 B2 - Document ID: US12109372B2 - Status: Granted - Kind: B2 - Application number: 17/109,537 - Filed: 2020-12-02 - Published: 2021-06-03 - Granted: 2024-10-08 - Earliest claimed: 2019-12-03 - Assignees: Boston Scientific Scimed, Inc. - Applicants: Boston Scientific Scimed, Inc. - Inventors: John Thomas Favreau; Stan Robert Gilbert; Jennifer Mague; Andrew Pic; Matthew LaPlaca; Jennifer Golden; Jennifer Whelehan; Travis Henchie - Web page: https://patentgrep.com/patent/US12109372B2 ## CPC - A61M 25/0026: {Multi-lumen catheters with stationary elements (catheter assemblies comprising a catheter in combination with a guide tube, sheath or sleeve A61M2025/0681; catheters comprising telescoping coaxial elements A61M2025/0175)} - A61M 25/0136: {Handles therefor} - A61B 17/00491: {Surgical glue applicators} - A61M 5/1452: {pressurised by means of pistons} - A61M 25/00: Catheters; Hollow probes (dilators A61M29/00; {peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00} ; for measuring or testing A61B; {materials for catheters A61L29/00}) - A61M 25/0043: {characterised by structural features} - A61M 25/09: Guide wires - A61B 2017/00495: {for two-component glue} - A61M 5/3294: {comprising means for injection of two or more media, e.g. by mixing} - A61M 2025/0037: {characterized by lumina being arranged side-by-side} - A61M 2025/0039: {characterized by lumina being arranged coaxially} - A61M 2025/091: {having a lumen for drug delivery or suction} - A61M 2025/09116: {Design of handles or shafts or gripping surfaces thereof for manipulating guide wires} - A61M 2205/073: Syringe, piston type - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A medical device may include a handle and a flexible sheath extending from the handle. The sheath may include a first chamber configured to receive a first agent and a second chamber configured to receive a second agent. Each of the first chamber and the second chamber may be disposed in a distal portion of the sheath. The sheath may also include a first piston received within the first chamber and a second piston received within the second chamber and at least one actuation element configured to transmit a force from the handle to each of the first piston and the second piston. In a first configuration, the first agent may be maintained within the first chamber and the second agent is maintained within the second chamber. In a second configuration, the first agent may be released from the first chamber to mix with the second agent. ## Claims ### Claim 1 A medical device comprising: a handle; a flexible sheath extending from the handle, wherein the sheath includes: a first chamber including a first agent and a second chamber including a second agent, wherein each of the first chamber and the second chamber is disposed in a distal portion of the sheath, wherein the first chamber surrounds the second chamber and includes a distally facing opening positioned distal to the second chamber, wherein the second chamber is defined by a first tube disposed within the first chamber, wherein a wall of the first tube includes a plurality of holes; a first piston received within the first chamber and a second piston received within the second chamber; and at least one actuation element configured to transmit a force from the handle to each of the first piston and the second piston; wherein, when the handle is in a first configuration, the first agent is maintained within the first chamber and the second agent is maintained within the second chamber, and wherein, when the handle is in a second configuration, the second agent is released from the second chamber to enter the first chamber and mix with the first agent. ### Claim 2 (depends on 1) The medical device of claim 1, wherein a distalmost end of the first tube is proximal of the distally facing opening of the first chamber. ### Claim 3 (depends on 1) The medical device of claim 1, wherein a central longitudinal axis of the first tube is approximately coaxial with a central longitudinal axis of the first chamber. ### Claim 4 (depends on 1) The medical device of claim 1, wherein the first piston has an outer perimeter and an inner perimeter, and wherein the second piston has an outer perimeter with a shape that is complementary to a shape of an inner wall of the first tube. ### Claim 5 (depends on 4) The medical device of claim 4, wherein the at least one actuation element includes a first actuation element that is a second tube defining a lumen, and wherein the at least one actuation element includes a second actuation element that is a wire within the lumen. ### Claim 6 (depends on 1) The medical device of claim 1, wherein the at least one actuation element includes a first flexible actuation element having a proximal end operatively coupled to the handle and a distal end operatively coupled to the first piston, and a second flexible actuation element having a proximal end operatively coupled to the handle and a distal end operatively coupled to the second piston. ### Claim 7 (depends on 1) The medical device of claim 1, wherein the sheath includes at least one barrier preventing a release of the first agent from the first chamber. ### Claim 8 (depends on 1) The medical device of claim 1, wherein the distal portion of the sheath is removably attached to a remainder of the sheath. ### Claim 9 (depends on 1) The medical device of claim 1, wherein the second agent is configured to be released radially outward from the first tube via the plurality of holes. ### Claim 10 (depends on 1) The medical device of claim 1, wherein the second agent includes a fluid or a powder. ### Claim 11 (depends on 1) The medical device of claim 1, wherein a diameter of each of the plurality of holes is less than 2 mm. ### Claim 12 A medical device comprising: a handle including an actuator; and a sheath extending from the handle, wherein a distal portion of the sheath includes: a first chamber including a first agent; a second chamber including a second agent; a tube disposed within the first chamber, wherein the tube has an internal lumen defining the second chamber, and wherein a wall of the tube includes a plurality of holes; and at least one actuation element is configured to transmit a force from the actuator to each of a first piston received within the first chamber and a second piston received within the second chamber; wherein each of the plurality of holes is configured to isolate the first agent from the second agent in the second chamber when the at least one actuation element receives no force and to release the second agent from the second chamber through the plurality of holes to mix with the first agent when the at least one actuation element receives the force. ### Claim 13 (depends on 12) The medical device of claim 12, wherein the at least one actuation element includes at least one of a wire, a tube, or a fluid. ### Claim 14 (depends on 12) The medical device of claim 12, wherein the at least one actuation element is a first actuation element, and further comprising a second actuation element, wherein the second actuation element includes at least one of a wire or a tube. ### Claim 15 A medical device comprising: a handle including an actuator; a sheath extending from the handle, wherein the sheath includes: a first chamber including a first agent and a second chamber including a second agent, wherein each of the first chamber and the second chamber is disposed in a distal portion of the sheath; and a first piston received within the first chamber and a second piston received within the second chamber; and a tube configured to transmit a force from the actuator to at least one of the first piston and the second piston, wherein the second chamber is defined by a first tube disposed within the first chamber, wherein a wall of the first tube includes a plurality of holes, each of the plurality of holes has a sufficiently small diameter and has a sufficient length through the wall of the tube such that the second agent does not pass through the plurality of holes until a force is exerted by the second piston, wherein a distalmost end of the first tube is proximal of an opening in a distalmost end of the sheath, the opening of the distalmost end of the sheath being coaxial with the first and second chambers. ### Claim 16 (depends on 15) The medical device of claim 15, wherein the wall of the first tube including the plurality of holes is a radial wall. ### Claim 17 (depends on 12) The medical device of claim 12, wherein each of the plurality of holes has a sufficiently small diameter and has a sufficient length through the wall of the tube such that the second agent does not pass through the plurality of holes until a force is exerted by the second piston. ### Claim 18 (depends on 12) The medical device of claim 12, wherein the sheath includes at least one barrier preventing a release of the first agent from the first chamber; wherein the at least one barrier is positioned at a distalmost opening of the sheath. ### Claim 19 (depends on 12) The medical device of claim 12, wherein a viscosity of each of the first agent and the second agent is sufficiently high to prevent the first agent and the second agent from passing through a distal opening of the sheath without a force being applied to the first piston.