# US 12,109,370 B2 · Arterial cannula which allows proximal and distal perfusion within a cannulated vessel > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,109,370 B2 - Document ID: US12109370B2 - Status: Granted - Kind: B2 - Application number: 16/592,640 - Filed: 2019-10-03 - Published: 2020-07-09 - Granted: 2024-10-08 - Earliest claimed: 2014-01-30 - Applicants: Tar Toong Victor Chao; Chong Hee Lim; Hock Heng Daniel Tan; Tze Kiat Ng - Inventors: Tar Toong Victor Chao; Chong Hee Lim; Hock Heng Daniel Tan; Tze Kiat Ng - Web page: https://patentgrep.com/patent/US12109370B2 ## CPC - A61M 25/007: {Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked} - A61M 1/3659: {Cannulae pertaining to extracorporeal circulation} - A61M 25/0029: {characterized by features relating to least one lumen located at the middle part of the catheter, e.g. slots, flaps, valves, cuffs, apertures, notches, grooves or rapid exchange ports (catheter shaft surface irregularities A61M2025/006)} - A61M 25/04: in the body, e.g. expansible {(A61M25/10, A61M16/0488 take precedence)} - A61M 25/10: Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00}) - A61M 2205/583: by visual feedback - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A cannula includes a first segment configured to reside entirely within a vessel. The first segment includes a proximal exit opening disposed nearer to the heart, and multiple fenestrations disposed distally away from the proximal exit opening near a cannulation site. The fenestrations in combination with the proximal exit opening enable simultaneous perfusion of blood into the cannulated vessel along proximal and distal directions. During a medical procedure, blood introduced into a vessel (e.g., the femoral artery) by way of the cannula can exit the cannula in a manner that provides concurrent blood flow in a first set of directions proximally towards the heart and a second set of directions distally away from the heart. Radially displaceable anchoring elements positionable adjacent to the vessel's superficial wall aid retention of the first segment in the vessel. The fenestrations and/or anchoring elements can be arranged obliquely around portions of the cannula's circumference. ## Claims ### Claim 1 A cannula structure configured for cannulating a tubular anatomical vessel of a body of a patient, the tubular anatomical vessel having a superficial wall, the cannula structure comprising: a first tube insertable into the tubular anatomical vessel through a cannulation point, the first tube having each of a lumen and an elongate length, the lumen extending through the first tube, the lumen for infusing and channeling into the tubular anatomical vessel a fluid, the first tube comprising: a distal fluid input configured for receiving the fluid; a first segment having a first lumen, the first lumen extending through the first segment, the first lumen aligned with the lumen of the first tube, the first lumen fluidically coupled to the distal fluid input, wherein the first segment has a lengthwise axis that extends through the first lumen, wherein the first segment is configured for residing entirely internal to the cannulated tubular anatomical vessel, and wherein a distal portion of the first segment includes a flexible or semi-flexible angulatable section; a second segment having a second lumen aligned with and integrally fluidically coupled to the first lumen, wherein the second segment is distal to the first segment and the flexible or semi-flexible angulatable section, and wherein the first and second lumens form the lumen of the first tube; fluid outputs carried by the first segment and coupled to the distal fluid input, each fluid output configured to discharge some of the fluid received at the distal fluid input into the tubular anatomical vessel along (a) a proximal flow direction that is toward the patient's heart and parallel to the lengthwise axis of the first segment, or (b) a distal flow direction that is away from the patient's heart, parallel to the lengthwise axis of the first segment, and opposite to the proximal flow direction; and an anchoring assembly proximal to the second segment of the first tube and carried by the first segment of the first tube, wherein the anchoring assembly is configured to be inserted inside the tubular anatomical vessel during cannulation of the tubular anatomical vessel and is further configured to engage with the superficial wall of the cannulated tubular anatomical vessel adjacent or just internal to the cannulation point, wherein the anchoring assembly comprises at least one outwardly or radially displaceable structure that is coupled to an inflation tube, and which is outwardly or radially displaceable away from the first lumen beyond an exterior surface of the first segment in response to clinician application of a positive pressure that introduces air or liquid into the anchoring assembly through the inflation tube, and wherein the anchoring assembly has a distal portion disposed closest to a distal end of the cannula structure at a first circumferential position about the first segment and a proximal portion disposed closest to a proximal end of the cannula structure at a distinct second circumferential position about the first segment such that the distal portion of the anchoring assembly is closer to the second segment of the first tube than the proximal portion of the anchoring assembly, and the anchoring assembly is arranged obliquely with respect to the lengthwise axis of the first segment prior to angulation of the flexible or semi-flexible angulatable section of the first segment, wherein the flexible or semi-flexible angulatable section of the first segment is configured to displace a portion of the first segment by way of bending to establish an intended angular orientation between the first segment and the second segment once the fluid outputs carried by the first segment have entered the tubular anatomical vessel; and wherein among the fluid outputs carried by the first segment: each fluid output that is configured to discharge some of the fluid in the proximal flow direction is disposed at a proximal end of the first segment, and each fluid output that is configured to discharge some of the fluid in the distal flow direction is disposed contiguous to the anchoring assembly. ### Claim 2 (depends on 1) The cannula structure of claim 1, wherein the anchoring assembly comprises an inflatable cuff that is disposed about the first segment, and wherein the inflation tube is fluidically coupled to a one-way valve assembly and the inflatable cuff. ### Claim 3 (depends on 1) The cannula structure of claim 1, wherein each fluid output that is configured to discharge some of the fluid in the distal flow direction is carried only on a lower half section of the first segment. ### Claim 4 (depends on 1) The cannula structure of claim 1, wherein the anchoring assembly comprises a plurality of outwardly or radially displaceable structures disposed about portions of a circumference of the first segment, and wherein the plurality of outwardly or radially displaceable structures includes a first outwardly or radially displaceable structure disposed closest to the cannula structure's distal end, and a second outwardly or radially displaceable structure distinct from the first outwardly or radially displaceable structure and disposed proximal to the first outwardly or radially displaceable structure. ### Claim 5 (depends on 4) The cannula structure of claim 4, wherein among the fluid outputs carried by the first segment that are configured to discharge some of the fluid in the distal flow direction, a first fluid output is configured to discharge a first portion of the fluid in the distal flow direction and a second fluid output is configured to discharge a second portion of the fluid in the distal flow direction, wherein the first fluid output and the second fluid output are disposed at different distal locations relative to each other along the first segment and different circumferential locations relative to each other along the first segment, and wherein the first outwardly or radially displaceable structure is disposed distal to the first fluid output, and the second outwardly or radially displaceable structure is disposed distal to the second fluid output. ### Claim 6 (depends on 1) The cannula structure of claim 1, wherein the anchoring assembly comprises (a) an inflatable cuff, or (b) a rigid or generally rigid annular fluid transport channel fluidically coupled to the at least one outwardly or radially displaceable structure. ### Claim 7 (depends on 1) The cannula structure of claim 1, further comprising a second tube configured for mating engagement with the first tube and which serves as a vessel dilator when engaged with the first tube, wherein a combined structure formed of the first tube engaged with the second tube is insertable into the tubular anatomical vessel. ### Claim 8 (depends on 1) The cannula structure of claim 1, wherein among the fluid outputs carried by the first segment, a ratio of a total cross sectional area through which fluid can be discharged in the distal flow direction to a total cross sectional area through which fluid can be discharged in the proximal flow direction is between 10 to 40%. ### Claim 9 (depends on 8) The cannula structure of claim 8, wherein each fluid output carried by the first segment that is configured to discharge some of the fluid in the distal flow direction is carried only on a lower half section of the first segment. ### Claim 10 A cannula structure configured for cannulating a tubular anatomical vessel of a body of a patient, the tubular anatomical vessel having a superficial wall, the cannula structure comprising: a first tube insertable into the tubular anatomical vessel through a cannulation point, the first tube having each of a lumen and an elongate length, the lumen extending through the first tube, the lumen for infusing and channeling into the tubular anatomical vessel a fluid, the first tube comprising: a distal fluid input configured for receiving the fluid; a first segment having a first lumen, the first lumen extending through the first segment, the first lumen aligned with the lumen of the first tube, the first lumen fluidically coupled to the distal fluid input, wherein the first segment has a lengthwise axis that extends through the first lumen, wherein the first segment is configured for residing entirely internal to the cannulated tubular anatomical vessel, and wherein a distal portion of the first segment includes a flexible or semi-flexible angulatable section; a second segment having a second lumen aligned with and integrally fluidically coupled to the first lumen, wherein the second segment is distal to the first segment and the flexible or semi-flexible angulatable section, and wherein the first and second lumens form the lumen of the first tube; a plurality of fluid outputs coupled to the distal fluid input and configured for discharging the fluid into the tubular anatomical vessel, wherein the plurality of fluid outputs comprises: an exit opening disposed near or at a proximal end of the first segment, the exit opening configured for outputting or discharging a first portion of the fluid into the tubular anatomical vessel along a proximal flow direction that is (a) toward the patient's heart, and (b) parallel to the lengthwise axis of the first segment; and a set of fenestrations carried by distal portions of the first segment along portions of a length of the first segment and about portions of a circumference of the first segment on the flexible or semi-flexible angulatable section of the first segment, the set of fenestrations configured for outputting or discharging a second portion of the fluid into the tubular anatomical vessel such that the second portion of the fluid flows along a distal flow direction that is (a) away from the patient's heart, (b) parallel to the lengthwise axis of the first segment, and (c) opposite to the proximal flow direction; and an anchoring assembly proximal to the second segment of the first tube and carried by the first segment of the first tube near or adjacent and distal to the set of fenestrations, wherein the anchoring assembly is configured for engagement with the superficial wall of the cannulated tubular anatomical vessel adjacent or just internal to the cannulation point, wherein the anchoring assembly comprises at least one outwardly or radially displaceable structure that is coupled to an inflation tube, and which is outwardly or radially displaceable away from the first lumen beyond an exterior surface of the first segment in response to clinician application of a positive pressure that introduces air or liquid into the anchoring assembly through the inflation tube, and wherein the anchoring assembly has a distal portion disposed closest to a distal end of the cannula structure at a first circumferential position about the first segment and a proximal portion disposed closest to a proximal end of the cannula structure at a distinct second circumferential position about the first segment such that the distal portion of the anchoring assembly is closer to the second segment of the first tube than the proximal portion of the anchoring assembly, the anchoring assembly is arranged obliquely with respect to the lengthwise axis of the first segment prior to angulation of the flexible or semi-flexible angulatable section of the first segment, and each fenestration carried by the distal portions of the first segment along the portions of the length of the first segment and about the portions of the circumference of the first segment on the flexible or semi-flexible angulatable section of the first segment is disposed proximally adjacent or contiguous to the anchoring assembly after the cannula structure has been inserted into and anchored within the cannulated tubular anatomical vessel, and further wherein the anchoring assembly comprises an inflatable cuff that is disposed about the first segment, wherein the inflation tube is fluidically coupled to a one-way valve assembly and the inflatable cuff, wherein the inflatable cuff comprises an elliptical or circular ring type structure that comprises an inner layer, an outer layer, a chamber between the inner layer and the outer layer, and a plurality of flange members integrally carried by or formed from portions of the outer layer or structurally and/or fluidically coupled to or formed from portions of the outer layer. ### Claim 11 A cannula structure configured for cannulating a tubular anatomical vessel of a body of a patient, the tubular anatomical vessel having a superficial wall, the cannula structure comprising: a first tube insertable into the tubular anatomical vessel through a cannulation point, the first tube having each of a lumen and an elongate length, the lumen extending through the first tube, the lumen for infusing and channeling into the tubular anatomical vessel a fluid, the first tube comprising: a distal fluid input configured for receiving the fluid; a first segment having a first lumen, the first lumen extending through the first segment, the first lumen aligned with the lumen of the first tube, the first lumen fluidically coupled to the distal fluid input, wherein the first segment has a lengthwise axis that extends through the first lumen, wherein the first segment is configured for residing entirely internal to the cannulated tubular anatomical vessel, and wherein a distal portion of the first segment includes a flexible or semi-flexible angulatable section; a second segment having a second lumen aligned with and integrally fluidically coupled to the first lumen, wherein the second segment is distal to the first segment and the flexible or semi-flexible angulatable section, and wherein the first and second lumens form the lumen of the first tube; a plurality of fluid outputs coupled to the distal fluid input and configured for discharging the fluid into the tubular anatomical vessel, wherein the plurality of fluid outputs comprises: an exit opening disposed near or at a proximal end of the first segment, the exit opening configured for outputting or discharging a first portion of the fluid into the tubular anatomical vessel along a proximal flow direction that is (a) toward the patient's heart, and (b) parallel to the lengthwise axis of the first segment; and a set of fenestrations carried by distal portions of the first segment along portions of a length of the first segment and about portions of a circumference of the first segment on the flexible or semi-flexible angulatable section of the first segment, the set of fenestrations configured for outputting or discharging a second portion of the fluid into the tubular anatomical vessel such that the second portion of the fluid flows along a distal flow direction that is (a) away from the patient's heart, (b) parallel to the lengthwise axis of the first segment, and (c) opposite to the proximal flow direction; and an anchoring assembly proximal to the second segment of the first tube and carried by the first segment of the first tube near or adjacent and distal to the set of fenestrations, wherein the anchoring assembly is configured for engagement with the superficial wall of the cannulated tubular anatomical vessel adjacent or just internal to the cannulation point, wherein the anchoring assembly comprises at least one outwardly or radially displaceable structure that is coupled to an inflation tube, and which is outwardly or radially displaceable away from the first lumen beyond an exterior surface of the first segment in response to clinician application of a positive pressure that introduces air or liquid into the anchoring assembly through the inflation tube, and wherein the anchoring assembly has a distal portion disposed closest to a distal end of the cannula structure at a first circumferential position about the first segment and a proximal portion disposed closest to a proximal end of the cannula structure at a distinct second circumferential position about the first segment such that the distal portion of the anchoring assembly is closer to the second segment of the first tube than the proximal portion of the anchoring assembly, the anchoring assembly is arranged obliquely with respect to the lengthwise axis of the first segment prior to angulation of the flexible or semi-flexible angulatable section of the first segment, and each fenestration carried by the distal portions of the first segment along the portions of the length of the first segment and about the portions of the circumference of the first segment on the flexible or semi-flexible angulatable section of the first segment is disposed proximally adjacent or contiguous to the anchoring assembly after the cannula structure has been inserted into and anchored within the cannulated tubular anatomical vessel, and further wherein the anchoring assembly comprises an inflatable cuff that comprises an elliptical or circular ring type structure, wherein the at least one outwardly or radially displaceable structure is formed as an outer layer of the inflatable cuff and a plurality of flange members carried by the outer layer and which are configured to protrude away from the first lumen in response to inflation of the inflatable cuff. ### Claim 12 (depends on 11) The cannula structure of claim 11, wherein each of the plurality of flange members protrudes away from and beyond the exterior surface of the first segment responsive to inflation of the inflatable cuff while the inflatable cuff (i) resides at least partially within a thickness of a wall of the first segment, or (ii) remains internal to the exterior surface of the first segment.