# US 12,109,334 B2 · Three dimensional electrospun biomedical patch for facilitating tissue repair

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- Number: US 12,109,334 B2
- Document ID: US12109334B2
- Status: Granted
- Kind: B2
- Application number: 18/159,412
- Filed: 2023-01-25
- Published: 2023-11-02
- Granted: 2024-10-08
- Earliest claimed: 2018-09-14
- Assignees: Washington University
- Applicants: Washington University
- Inventors: Matthew R. MacEwan
- Web page: https://patentgrep.com/patent/US12109334B2

## CPC

- A61L 31/04: Macromolecular materials
- A61F 13/00987: {Apparatus or processes for manufacturing non-adhesive dressings or bandages}
- A61F 13/01017: {synthetic, e.g. polymer based}
- A61F 13/01034: {characterised by a property}
- A61L 15/26: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)}
- A61L 15/44: Medicaments
- A61L 15/64: specially adapted to be resorbable inside the body
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 27/60: Materials for use in artificial skin
- B29C 48/18: the components being layers
- B32B 5/022: {Non-woven fabric}
- B32B 5/26: another layer {next to it} also being fibrous or filamentary {(relative arrangement of fibres or filaments of different layers B32B5/12)}
- B32B 7/02: Physical, chemical or physicochemical properties
- B32B 7/12: using interposed adhesives or interposed materials with bonding properties
- D01D 5/0007: {Electro-spinning (non-woven fabrics produced by electro-spinning D04H1/728)}
- D01D 5/0038: {the fibre formed by solvent evaporation, i.e. dry electro-spinning}
- D01D 5/0061: {characterised by the electro-spinning apparatus}
- D01D 5/0076: {characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid (D01D5/0046 takes precedence)}
- D04H 1/4374: using different kinds of webs, e.g. by layering webs
- D04H 1/728: by electro-spinning {(electro-spinning methods and apparatus D01D5/0007)}
- D04H 3/16: with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
- A61F 13/02: Adhesive bandages or dressings
- A61L 2300/414: Growth factors
- A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
- A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
- A61L 2430/20: for reconstruction of the heart, e.g. heart valves
- A61L 2430/32: for nerve reconstruction
- B32B 2250/20: All layers being fibrous or filamentary
- B32B 2262/0276: Polyester fibres
- B32B 2307/518: bi-axially
- B32B 2307/54: Yield strength; Tensile strength
- B32B 2307/726: Permeability to liquids, absorption
- B32B 2307/7265: Non-permeable
- B32B 2556/00: Patches, e.g. medical patches, repair patches
- D10B 2509/00: Medical; Hygiene
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- B29C: SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING (making preforms B29B11/00; making laminated products by combining previously unconnected layers which become one product whose layers will remain together B32B37/00 - B32B41/00)
- B32B: LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- D01D: MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D04H: MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL (weaving D03; knitting D04B; braiding D04C; net-making D04G; sewing D05B; tufting D05C; finishing non-woven fabrics D06); FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING {; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION}(non-woven fabrics having an intermediate or external layer of a different kind, e.g. of woven fabric, B32B)
- D10B: INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES

## Abstract

A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.

## Claims

### Claim 1

A three-dimensional electrospun biomedical patch for facilitating tissue repair, the three-dimensional electrospun biomedical patch comprising:
a structure of bioresorbable deposited electrospun fibers generated by electrospinning a first polymer composition and a second polymer composition, the deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a period of time upon application of the three-dimensional electrospun biomedical patch to a tissue, wherein the period of time is less than twelve months, wherein the structure of deposited electrospun fibers comprise one or more high density fiber deposition areas and one or more low density fiber deposition areas, and the one or more high density fiber deposition areas and the one or more low density fiber deposition areas are entangled; and
a plurality of voids within the structure of bioresorbable deposited electrospun fibers, the plurality of voids comprising one or more voids between 10 μm and 10 cm in length,
wherein the three-dimensional electrospun biomedical patch is pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.

### Claim 2 (depends on 1)

The three-dimensional electrospun biomedical patch of claim 1, further comprising a spatial arrangement formed by the deposited electrospun fibers.

### Claim 3 (depends on 2)

The three-dimensional electrospun biomedical patch of claim 2, wherein the spatial arrangement comprises an asymmetrical arrangement.

### Claim 4 (depends on 2)

The three-dimensional electrospun biomedical patch of claim 2, wherein the spatial arrangement comprises a repeating pattern.

### Claim 5 (depends on 1)

The three-dimensional electrospun biomedical patch of claim 1, wherein the tissue comprises skin.

### Claim 6 (depends on 1)

The three-dimensional electrospun biomedical patch of claim 1, wherein the tissue comprises one or more of skin, dura mater, heart valve leaflets, cardiac tissue, trachea, gastrointestinal tract, pericardium, muscle, connective tissue, intestinal tissue, stomach tissue, bone, gastrointestinal tract, or mucosa.

### Claim 7 (depends on 1)

The three-dimensional electrospun biomedical patch of claim 1, wherein the first polymer composition comprises poly(lactic-co-glycolic acid).

### Claim 8 (depends on 1)

The three-dimensional electrospun biomedical patch of claim 1, wherein the first polymer composition comprises glycolic acid, and wherein the second polymer composition comprises caprolactone.

### Claim 9 (depends on 1)

The three-dimensional electrospun biomedical patch of claim 1, further comprising one or more pores, wherein the one or more pores vary between 10 μm and 10 cm.