# US 12,109,331 B2 · Medical device, and method for manufacturing medical device

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- Number: US 12,109,331 B2
- Document ID: US12109331B2
- Status: Granted
- Kind: B2
- Application number: 17/467,637
- Filed: 2021-09-07
- Published: 2021-12-30
- Granted: 2024-10-08
- Earliest claimed: 2019-03-08
- Assignees: Olympus Corporation
- Applicants: Olympus Corporation
- Inventors: Takashi Magara
- Web page: https://patentgrep.com/patent/US12109331B2

## CPC

- A61L 29/16: Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)}
- A61B 1/00: Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes (examination of body cavities or body tracts using ultrasonic, sonic or infrasonic waves A61B8/12; endoscopic instruments for taking cell samples or for biopsy A61B10/04); Illuminating arrangements therefor (for the eyes A61B3/00)
- A61B 1/005: Flexible endoscopes
- A61L 29/041: {obtained by reactions only involving carbon-to-carbon unsaturated bonds}
- A61L 29/049: {Mixtures of macromolecular compounds}
- A61L 31/048: {obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence)}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- B05D 1/36: Successively applying liquids or other fluent materials, e.g. without intermediate treatment
- B32B 27/30: comprising vinyl {(co)polymers; comprising acrylic (co)polymers}
- B32B 27/38: comprising epoxy resins
- C09D 5/00: Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced {(electrically insulating plastics, resins or waxes H01B3/30)}; Filling pastes
- C09D 163/00: Coating compositions based on epoxy resins; Coating compositions based on derivatives of epoxy resins
- C09D 201/02: characterised by the presence of specified groups {, e.g. terminal or pendant functional groups}
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2420/02: Methods for coating medical devices
- C08L 27/18: Homopolymers or copolymers or tetrafluoroethene
- C08L 27/20: Homopolymers or copolymers of hexafluoropropene
- C08L 63/00: Compositions of epoxy resins; Compositions of derivatives of epoxy resins
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02)
- B32B: LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- C09D: COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR (cosmetics A61K; processes for applying liquids or other fluent materials to surfaces, in general, B05D; staining wood B27K5/02; glazes or vitreous enamels C03C; natural resins, French polish, drying-oils, driers, turpentine, per se, C09F; polishing compositions other than French polish, ski waxes C09G; adhesives or use of materials as adhesives C09J; materials for sealing or packing joints or covers C09K3/10; materials for stopping leaks C09K3/12; processes for the electrolytic or electrophoretic production of coatings C25D)
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)

## Abstract

A medical device includes a resin base including one or more than one material selected from a group consisted by an ethylene propylene resin containing fluorine, a styrene resin containing fluorine, an olefin resin containing fluorine, a vinyl chloride resin containing fluorine, a polyester resin containing fluorine, a polyurethane resin containing fluorine, and a nylon resin containing fluorine; an underlayer formed on the resin base, the underlayer including an oxazolidone ring; and an epoxy resin layer formed on the underlayer.

## Claims

### Claim 1

A medical device, comprising:
a resin base including one or more than one material selected from the group consisting of an ethylene propylene resin containing fluorine, a styrene resin containing fluorine, an olefin resin containing fluorine, a vinyl chloride resin containing fluorine, a polyester resin containing fluorine, a polyurethane resin containing fluorine, and a nylon resin containing fluorine;
an underlayer formed on the resin base, the underlayer including an oxazolidone ring; and
an epoxy resin layer formed on the underlayer,
wherein at least one of the resin base and the underlayer comprises a substance having an unsaturated bond of carbon atoms, and the resin base and the underlayer are composited in a three-dimensional uneven structure.

### Claim 2 (depends on 1)

The medical device according to claim 1, wherein a composite layer including the material of the resin base is formed at least in a lower portion of the underlayer.

### Claim 3 (depends on 2)

The medical device according to claim 2, wherein a thickness of the composite layer is equal to or more than 2 nanometers and equal to or less than 800 nanometers.

### Claim 4 (depends on 1)

The medical device according to claim 1, wherein:
the medical device is an endoscope comprising an insertion portion and an operating portion;
the insertion portion comprises a flexible tube portion, a bending portion, and a distal end portion;
the bending portion is connected to a proximal end side of the distal end portion, and the bending portion is configured to change an orientation of the distal end portion;
the flexible tube portion connects the operation portion and the bending portion;
the flexible tube portion has a first external skin comprising the resin base;
the bending portion has a second external skin comprising the resin base;
an adhesion portion is provided at a position where the first and second external skins are adjacent to each other, and covers an external circumference of the first external skin and an external circumference of the second external skin;
the adhesion portion comprises the underlayer and the epoxy resin; and
underlayer of the adhesion portion is formed on the resin base of the first external skin and the resin base of the second external skin.

### Claim 5 (depends on 1)

The medical device according to claim 1, wherein the resin base contains, as the substance having the unsaturated bond of carbon atoms, an acrylic resin containing fluorine, a vinyl ester resin containing fluorine, a vinyl acetate resin containing fluorine, or a vinylidene resin containing fluorine.

### Claim 6 (depends on 1)

The medical device according to claim 1, wherein the underlayer contains as the substance having the unsaturated bond of carbon atoms, 2-isocyanatoethylacrylate or 2-isocyanatoethyl methacrylate.

### Claim 7 (depends on 1)

The medical device according to claim 1, wherein the underlayer contains as the substance having the unsaturated bond of carbon atoms, 2-isocyanatoethylacrylate, 2-isocyanatoethyl methacrylate, methacrylic acid, 2-(0-[1′-methylpropyridaneamino] carboxyamino) ethyl, 2-[(3,5-dimethylpyrazolyl) carbonylamino] ethyl methacrylate, 1,1-(bisacryloyloxymethyl) ethyl isocyanate, or 2-isocyanatoethylacrylate.

### Claim 8 (depends on 1)

A method for manufacturing the medical device of claim 1, the method comprising:
preparing the resin base including one or more than one material selected from the group consisting of an ethylene propylene resin containing fluorine, a styrene resin containing fluorine, an olefin resin containing fluorine, a vinyl chloride resin containing fluorine, a polyester resin containing fluorine, a polyurethane resin containing fluorine, and a nylon resin containing fluorine;
preparing a solution in which isocyanate is mixed in an organic solvent;
adhering the solution on a surface of the resin base material and drying the solution to form the underlayer; and
coating an epoxy resin raw material on the underlayer and curing the epoxy resin raw material to form the epoxy resin layer.

### Claim 9 (depends on 8)

The method according to claim 8, further comprising forming a composite layer in a lower portion of the underlayer, wherein the material of the underlayer and the material of the resin base are mixed in the composite layer.