# US 12,109,292 B2 · Bioflavonoid compositions and their use

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- Number: US 12,109,292 B2
- Document ID: US12109292B2
- Status: Granted
- Kind: B2
- Application number: 17/286,191
- Filed: 2019-10-18
- Published: 2023-02-09
- Granted: 2024-10-08
- Earliest claimed: 2018-10-18
- Assignees: Oraldent Limited
- Applicants: Oraldent Limited; Richard Thomas
- Inventors: Howard Thomas
- Web page: https://patentgrep.com/patent/US12109292B2

## CPC

- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 8/042: {Gels}
- A61K 8/27: Zinc; Compounds thereof
- A61K 8/361: {Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof}
- A61K 8/602: {Glycosides, e.g. rutin}
- A61K 8/88: Polyamides
- A61Q 11/02: Preparations for deodorising, bleaching or disinfecting dentures
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The present invention relates to pharmaceutical compositions and their use in oral hygiene. More particularly, the compositions comprise one or more flavonoids, such as naringin and neohesperidine and polylysine and/or caprylic acid and/or a zinc salt. Such compositions may be in the form of, for example, a solution, gel, spray, chewing gum or paste suitable for use in the oral cavity. The composition may be used in reducing bacterial numbers on teeth, gums or other surfaces in the oral cavity.

## Claims

### Claim 1

A composition suitable for use in the oral cavity for treating a condition selected from the group consisting of gum disease and plaque formation wherein the composition comprises ε-polylysine of molecular weight of 3000 Da to 5000 Da and caprylic acid, and a mixture of flavonoids extractable from bitter oranges comprising neoeriocitrin, isonaringin, naringin, hesperidin, neohesperidin, neodiosmin, naringenin, poncirin and rhiofolin, and wherein the ratio of flavonoids to &-polylysine and caprylic acid is 25:1 to 3:1 (wt/wt), and the concentration of flavonoids is 0.05 to 6 wt-%.

### Claim 2 (depends on 1)

A composition as claimed in claim 1 which comprises a mixture of flavonoids comprising 40% to 65% of naringin (wt/wt of flavonoids) and 20% to 35% of neohesperidin (wt/wt of flavonoids present).

### Claim 3 (depends on 1)

A composition as claimed in claim 1 wherein the composition comprises 0.06% to 4% of bioflavonoids and 30 mg/L to 240 mg/L of ε-polylysine.

### Claim 4 (depends on 1)

A composition as claimed in claim 1 for use in reducing bacterial numbers on teeth, gums or other surfaces within the oral cavity.

### Claim 5 (depends on 4)

A composition for use as claimed in claim 4 in the form of a solution, gel, spray, chewing gum or paste.

### Claim 6 (depends on 4)

A composition for use as claimed in claim 4 in the form of a toothpaste or mouthwash.

### Claim 7 (depends on 1)

A toothpaste or mouthwash which comprises a composition as set forth in claim 1.

### Claim 8 (depends on 7)

A toothpaste or mouthwash as claimed in claim 7 for use in treating gum disease or reducing plaque formation.

### Claim 9 (depends on 1)

A gel, a spray or a chewing gum which comprises a composition as set forth in claim 1.

### Claim 10 (depends on 9)

A gel, a spray or a chewing gum as claimed in claim 9 for use in treating gum disease or reducing plaque formation.