# US 12,109,285 B2 · Zinc phosphate complex for oral care

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- Number: US 12,109,285 B2
- Document ID: US12109285B2
- Status: Granted
- Kind: B2
- Application number: 15/539,748
- Filed: 2014-12-26
- Published: 2017-12-07
- Granted: 2024-10-08
- Earliest claimed: 2014-12-26
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Baohua Qiao; Long Pan; Gregory Szewczyk; Ravi Subramanyam
- Web page: https://patentgrep.com/patent/US12109285B2

## CPC

- A61K 8/27: Zinc; Compounds thereof
- A61K 6/20: Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
- A61K 6/74: comprising phosphorus-containing compounds
- A61K 8/24: Phosphorous; Compounds thereof
- A61K 33/42: Phosphorus; Compounds thereof
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/58: Metal complex; Coordination compounds
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

An oral care composition having a soluble zinc polyphosphate complex made by combining ingredients including an inorganic zinc salt, and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of treating a subject suffering from dentinal sensitivity applying the oral care composition to the teeth and gums of the subject.

## Claims

### Claim 1

An oral care composition, comprising:
a soluble zinc polyphosphate complex where the phosphorous to zinc mole ratio of the complex is 20:1, wherein the complex is made by combining zinc chloride and sodium hexametaphosphate and a solvent, wherein the solvent is water,
wherein the zinc chloride and the sodium hexametaphosphate are in sufficient amounts to provide a 20:1 mole ratio of phosphorus to zinc in the recited complex;
wherein when the soluble zinc polyphosphate complex is mixed with a protein a precipitate forms that can occlude dentinal tubules.

### Claim 2 (depends on 1)

The oral care composition of claim 1, wherein the zinc polyphosphate complex has a property of becoming insoluble at a pH ranging from about 5.5 to about 6.5.

### Claim 3 (depends on 1)

The oral care composition of claim 1, wherein the zinc polyphosphate complex is insoluble at a pH below 5.5 in the presence of salivary proteins.