# US 12,109,283 B2 · Safe and ecofriendly persistent sanitizing gel for topical application

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- Number: US 12,109,283 B2
- Document ID: US12109283B2
- Status: Granted
- Kind: B2
- Application number: 17/444,896
- Filed: 2021-08-11
- Published: 2022-07-21
- Granted: 2024-10-08
- Earliest claimed: 2021-01-20
- Assignees: Galaxy Surfactants Ltd.
- Applicants: Galaxy Surfactants Ltd.
- Inventors: Nirmal Koshti; Bhagyesh Jagannath Sawant; Kishor Pundalik Bari; Bilal Momin; Sushant Khandekar; Sukanya Talukdar; Parag Narendra Savla; Ananda Shamrao Hodage; Pooja Vaidya
- Web page: https://patentgrep.com/patent/US12109283B2

## CPC

- A01N 31/02: Acyclic compounds
- A61K 8/19: containing inorganic ingredients
- A61K 8/042: {Gels}
- A61K 8/922: {of vegetable origin}
- A61Q 17/005: {Antimicrobial preparations}
- A61K 2800/413: Nanosized, i.e. having sizes below 100 nm
- A61K 2800/48: Thickener, Thickening system
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention discloses persistent antimicrobial protection of hands and/or surfaces of different objects using the hydro-alcoholic gel composition of the present invention. In particular, the invention provides water-resistant sanitizing hydro-alcoholic gel compositions based on ethyl alcohol, silver nanoparticles and fatty acids of Tung seed oil (Aleurites fordii). More particularly, it discloses the compositions that keep the surface sanitized well beyond the instant sanitization provided by volatile ethyl alcohol. The compositions of the present invention have ‘natural origin’ index of minimum 99% as per ISO 16128-2.

## Claims

### Claim 1

A safe and ecofriendly sanitizing hydro-alcoholic gel composition for topical application with instant and persistent antimicrobial activity comprising:
a) 60 to 70% by weight of ethyl alcohol;
b) 5 to 100 ppm by weight of silver nanoparticles;
c) 0.2 to 5% by weight of fatty acids derived from Tung seed oil, wherein at least about 80% of the fatty acids are α-eleostearic acid (ESA);
d) 0.2 to 2% by weight of carbohydrate based gelling agents/thickeners;
e) optionally, 1 to 5% by weight of skin benefiting agents; and
f) demineralized water to make up 100% w/w,
wherein at least a portion of the silver nanoparticles and at least a portion of the ESA are present in the form of ESA-silver nanoparticle complexes where the ESA acts as a ligand and prevents aggregation of the silver nanoparticles in the hydro-alcoholic gel composition, and
wherein the α-eleostearic acid-silver nanoparticle complexes exhibit a surface plasmon resonance UV absorbance at 460 nm.

### Claim 2 (depends on 1)

The sanitizing hydro-alcoholic gel composition as claimed in claim 1, wherein the fatty acids derived from Tung seed oil stabilize and immobilize the silver nanoparticles in the composition and thus provides a water repellent film and an antimicrobial shield for a prolong period after evaporation of the alcohol.

### Claim 3 (depends on 1)

The sanitizing hydro-alcoholic gel composition as claimed in claim 1, wherein the carbohydrate based gelling agents/thickeners are selected from hydroxyl ethyl cellulose, hydroxyl propyl cellulose and sodium hyaluronate.

### Claim 4 (depends on 1)

The sanitizing hydro-alcoholic gel composition as claimed in claim 1, wherein the composition comprises the skin benefiting agents.

### Claim 5 (depends on 4)

The sanitizing hydro-alcoholic gel composition as claimed in claim 4, wherein the skin benefiting agents are selected from soya protein hydrolyzate, glycerin, tea tree oil and Aloe vera leaf juice.

### Claim 6 (depends on 1)

The sanitizing hydro-alcoholic gel composition as claimed in claim 1, wherein the composition comprises 5 to 25 ppm by weight of the silver nanoparticles.

### Claim 7 (depends on 1)

The sanitizing hydro-alcoholic gel composition as claimed in claim 1, wherein the composition comprises 10 to 25 ppm by weight of the silver nanoparticles and 1 to 3% by weight of the fatty acids derived from Tung seed oil.

### Claim 8 (depends on 1)

A process for preparing a sanitizing hydro-alcoholic gel composition according to claim 1, comprising:
a) soaking a carbohydrate based gelling agent/thickener in demineralized water followed by adding ethyl alcohol to form a mixture;
b) adjusting the pH of the mixture to 6.5-7.5;
c) adding a stock solution to the mixture, the stock solution having demineralized water, silver nanoparticles, fatty acids derived from Tung seed oil where at least about 80% of the fatty acids are α-eleostearic acid (ESA), and optionally skin benefitting agents and stirring to obtain the hydro-alcoholic gel composition, wherein at least a portion of the silver nanoparticles and at least a portion of the ESA react to form ESA-silver nanoparticle complexes.

### Claim 9 (depends on 8)

The process as claimed in claim 8, wherein the hydro-alcoholic gel composition has a viscosity ranging from 200 cps to 2000 cps.

### Claim 10 (depends on 8)

The process as claimed in claim 8, wherein the pH of the mixture is adjusted using sodium hydroxide or citric acid.