Methods and kits for preparing radionuclide complexes
AssigneeTheragnostics Limited
InventorsPhilip Blower, Gregory Mullen
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Abstract
A method for preparing a complex comprising a radioisotope of gallium for use in radiotherapy or in a medical imaging procedure, said method comprising adding a gallium radioisotope solution obtained directly from a gallium radionuclide generator to a composition comprising a pharmaceutically acceptable buffer and optionally also a pharmaceutically acceptable basic reagent, in amounts sufficient to increase the pH to a level in the range of 3 to 8, wherein the composition further comprises a chelator that is able to chelate radioactive gallium within said pH range and at moderate temperature, said chelator being optionally linked to a biological targeting agent. Kits and compositions for use in the method are also described and claimed.
Claims7
A method for obtaining a molecular image of a patient in need thereof, the method comprising:
- (a) preparing radiolabeled DKFZ-PSMA-11, wherein said preparing comprises adding a 0.1 M HCL gallium radioisotope eluate to a chelator composition at a temperature of from 10° C. to 30° C., thereby producing a preparation of radiolabeled DKFZ-PSMA-11, wherein the chelator composition comprises:
- (i) an amount of a pharmaceutically acceptable buffer selected from a phosphate buffer or acetate buffer, wherein the amount of the buffer is sufficient to increase the pH of the preparation to a level in the range of from 3 to 8;
- and
- (ii) DKFZ-PSMA-11,
- wherein the chelator composition is lyophilized or freeze-dried and does not include an agent that inhibits a metal other than gallium, and
- wherein the 0.1 M HCL gallium radioisotope eluate is directly from a gallium-68 radionuclide generator without an additional purification step or concentration step;
- (b) administering the preparation of the radiolabeled DKFZ-PSMA-11 to the patient;
- and
- (c) obtaining the molecular image of the patient using a molecular imaging technique.
Dependencies are inferred from the claim text.