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US 12,109,276 B2Granted
Near-infrared dyes and conjugates for targeting tumors
AssigneeLahjavida, LLC
InventorsLyle D. Small, Ruizheng Wang, Shane M. Crippen
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Abstract
The design, synthesis, and functionalization of a conjugate including a tumor-targeting near-infrared (NIR) dye and a therapeutic agent and/or a diagnostic agent, whereby the NIR dye can function to target the therapeutic agent and/or diagnostic agent to tumor cells.
Claims12
A method of treating or killing tumor cells, comprising:
- administering a tumor-targeting conjugate to a subject, said conjugate comprising a heptamethine cyanine dye covalently bound to a magnetic nanoparticle via a linker;
- wherein the tumor-targeting component of said conjugate consists of said heptamethine cyanine dye;
- and
- inducing hyperthermia in said tumor cells via electromagnetic radiation having a frequency comprising kilohertz or megahertz;
- wherein said linker comprises one of the following compositions:
- wherein n is 3, 5, 8, 12, 22, 45, or 113.
3 more elements
Dependencies are inferred from the claim text.