Zika vaccines and immunogenic compositions, and methods of using the same
AssigneeTakeda Vaccines, Inc.
InventorsJill A Livengood, Hansi Dean, Htay Htay Han, Raman Rao, Jackie Marks, Gary Dubin, Laurence De Moerlooze, Hetal Patel, Sushma Kommareddy
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Abstract
The present disclosure relates to Zika virus vaccines and immunogenic compositions having one or more antigens from a Zika virus (e.g., a Zika virus clonal isolate, a non-human cell adapted Zika virus, etc.), and methods of treatments and uses thereof.
Claims30
A method of vaccinating against Zika virus infection in a human subject in need thereof, the method comprising administering to the human subject a vaccine or immunogenic composition comprising an antigen from a Zika virus, wherein the vaccine or immunogenic composition is administered as a multi dose administration comprising a first (prime) and a second (boost) administration and wherein administration of the vaccine or immunogenic composition induces 14 and/or 28 days after the boost administration a seroconversion rate of at least 80%, at least 90%, at least 95%, or 100% in a human subject population of at least 20 flavivirus naïve human subjects or at least 20 Zika virus seronegative human subjects.
A method of vaccinating against Zika virus infection in a human subject in need thereof, the method comprising administering to the human subject a vaccine or immunogenic composition comprising an antigen from a Zika virus, wherein the vaccine or immunogenic composition is administered as a single dose or prime administration and wherein administration of the vaccine or immunogenic composition induces 14 and/or 28 days after the single dose or prime administration a seroconversion rate of at least 60%, at least 70%, at least 80%, at least 90%, or at least 95% in a human subject population of at least 20 flavivirus naïve human subjects or at least 20 Zika virus seronegative human subjects.
A method of vaccinating against Zika virus infection in a human subject in need thereof, the method comprising administering to the human subject a vaccine or immunogenic composition comprising an antigen from a Zika virus, wherein the vaccine or immunogenic composition is administered as a multi dose administration comprising a first (prime) and a second (boost) administration and wherein administration of the vaccine or immunogenic composition induces 14 and/or 28 days after the prime administration a seroconversion rate of at least 60%, at least 70%, at least 80%, at least 90%, or at least 95% and 14 and/or 28 days after the boost administration a seroconversion rate of at least 90%, at least 95%, or 100% in a human subject population of at least 20 flavivirus naïve human subjects or at least 20 Zika virus seronegative human subjects.
A method of vaccinating against Zika virus disease in a fetus or newborn in need thereof, the method comprising administering to a pregnant human subject a vaccine or immunogenic composition comprising an antigen from a Zika virus, wherein the pregnant human subject adoptively transfers a vaccine effective amount of neutralizing antibodies against Zika virus to the fetus or newborn, wherein the vaccine or immunogenic composition is administered as a single dose or multi dose administration comprising a first (prime) and a second (boost) administration.
Dependencies are inferred from the claim text.