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US 12,109,257 B2Granted
Alphavirus neoantigen vectors
AssigneeGritstone Bio, Inc.
InventorsWade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
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Abstract
Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.
Claims20
A method for inducing an immune response in a subject, comprising:
- (A) administering a first vaccine composition, wherein the first vaccine composition comprises a chimpanzee adenovirus vector comprising a first neoantigen cassette;
- and
- (B) administering a second vaccine composition comprising an neoantigen expression system, wherein the neoantigen expression system comprises one or more vectors, wherein the one or more vectors each comprise:
- (a) an RNA alphavirus backbone, wherein the RNA alphavirus backbone comprises:
- (i) at least one promoter nucleotide sequence, and
- (ii) at least one polyadenylation (poly(A)) sequence;
- and
- (b) a second neoantigen cassette;
- and
- wherein the first neoantigen cassette and the second neoantigen cassette comprise
- at least one neoantigene-encoding nucleic acid sequence that is the same.
8 more elements
Dependencies are inferred from the claim text.