# US 12,109,245 B2 · Extract of aerial parts of Maca rich in polyphenols and composition comprising same

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- Number: US 12,109,245 B2
- Document ID: US12109245B2
- Status: Granted
- Kind: B2
- Application number: 16/580,826
- Filed: 2019-09-24
- Published: 2020-03-19
- Granted: 2024-10-08
- Earliest claimed: 2010-12-22
- Assignees: Laboratoires Expanscience
- Applicants: Laboratoires Expanscience
- Inventors: Alex Saunois; Caroline Baudouin; Sophie Leclere-Bienfait; Sebastien Garnier; Philippe Msika
- Web page: https://patentgrep.com/patent/US12109245B2

## CPC

- A61K 36/31: Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 31/197: the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid (carnitine A61K31/205)
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61K 31/201: having one or two double bonds, e.g. oleic, linoleic acids
- A61K 31/341: not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A61K 31/42: Oxazoles
- A61K 31/57: substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K 31/585: containing lactone rings, e.g. oxandrolone, bufalin
- A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K 31/717: Celluloses
- A61K 33/30: Zinc; Compounds thereof
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 36/48: Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K 36/54: Lauraceae (Laurel family), e.g. cinnamon or sassafras
- A61K 36/899: Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- A61K 45/00: Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 17/00: Drugs for dermatological disorders
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/805: Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.

## Claims

### Claim 1

A method for treating obesity, treating cellulite, reducing wrinkles, increasing skin elasticity, and/or slimming, comprising administering to a subject in need thereof an effective amount of a composition comprising an extract of Maca leaves or leafy stems,
wherein said extract comprises at least 5% polyphenols by weight, expressed in gallic acid equivalents, with respect to the dry weight of the extract,
wherein said polyphenols have a flavonoid content greater than 2% expressed in rutin equivalents, with respect to the total dry weight of the extract.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said composition contains 0.001 to 10% by weight of said extract, expressed as a percentage of dry extract.

### Claim 3 (depends on 1)

The method according to claim 1, wherein said flavonoids contain quercetin, kaempferol, derivatives thereof or mixtures thereof.

### Claim 4 (depends on 3)

The method according to claim 3, wherein said flavonoids contain quercetin, kaempferol, derivatives thereof or mixtures thereof at a concentration of at least 30% by weight, expressed in gallic acid equivalents, with respect to the total weight of the flavonoids.

### Claim 5 (depends on 4)

The method according to claim 4, wherein said flavonoids contain quercetin, kaempferol, derivatives thereof or mixtures thereof at a concentration of at least 50% by weight, expressed in gallic acid equivalents, with respect to the total weight of the flavonoids.

### Claim 6 (depends on 1)

The method according to claim 1, wherein said composition further comprises a suitable excipient.

### Claim 7 (depends on 1)

The method according to claim 1, wherein said extract is an extract of Maca leaves.

### Claim 8 (depends on 1)

The method according to claim 1, wherein said extract is a glycol/water or glycerol/water extract.

### Claim 9 (depends on 1)

The method according to claim 1, wherein said composition further comprises a compound selected from the group consisting of emollients, moisturizing agents, keratoregulators, keratolytics, skin barrier healing and/or remodeling agents, PPAR, RXR or LXR agonists, sebo-regulating agents, anti-irritant and/or anti-inflammatory and/or soothing agents, anti-oxidant agents, anti-ageing agents, depigmenting or hypopigmenting agents, pigmenting agents, lipolytic agents or lipogenesis inhibitors or anti-cellulite or slimming agents, mineral or organic sun filters and screens, antifungal compounds, preservatives, antibacterial agents, pre and probiotics, antibiotics and immunomodulators.

### Claim 10 (depends on 1)

The method according to claim 1, wherein said composition further comprises a compound selected from:
skin barrier healing and/or remodelling agents, optionally panthenol, arabinogalactan and zinc oxide,
sebo-regulating agents, optionally chosen from the group consisting of 5-alpha reductase inhibitors, zinc derivatives, spironolactone, and linoleic acid,
anti-inflammatory and/or anti-irritant and/or soothing agents, optionally arabinogalactan,
hypopigmenting or depigmenting agents, optionally N-undecylenoyl-L-phenylalanine,
mineral and/or organic sun screens or filters, optionally UVB and/or UVA sun filters or screens, and
preservatives optionally chosen from capryloyl glycine, glyceryl caprylate, hexanediol, sodium levulinate, zinc and copper derivatives.

### Claim 11 (depends on 1)

The method according to claim 1, wherein said composition is formulated for topical or oral administration.

### Claim 12 (depends on 1)

The method according to claim 1 for treating obesity.

### Claim 13 (depends on 1)

The method according to claim 1 for treating cellulite and/or for slimming.

### Claim 14 (depends on 1)

The method according to claim 1 for reducing wrinkles and/or increasing skin elasticity.