Use of alveolar or airway organoids for the treatment of lung diseases and disorders
AssigneeChildren's Medical Center Corporation
InventorsCarla F. Kim, Sharon M. Louie, Erhan Ararat, David Raiser
Life of this patent
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Abstract
Various aspects described herein provide methods of generating alveolar or alveolar/airway organoids from a population of lung cells to differentiate into alveolar or alveolar/airway organoids. Also provided herein are methods and compositions for treating lung disease comprising transplantation of the alveolar or alveolar/airway organoids, or a cell isolated therefrom to a subject.
Claims17
A method for treating a lung disease or disorder, or a lung injury, in a subject in need thereof, the method comprising administering to a subject, intratracheally, a therapeutically effective amount of a composition comprising an alveolar organoid or an isolated cell thereof,
- wherein the alveolar organoid is provided or produced in vitro or ex vivo from a lung cell by culturing the lung cell in a 3-dimensional culture for a time and under conditions sufficient to produce the alveolar organoid,
- wherein administering is transplanting, and
- wherein the alveolar organoid or cell thereof functionally engrafts into the lung after transplanting thereby treating the lung disease or disorder or lung injury in the subject.
Dependencies are inferred from the claim text.